Closantel, identified by its CAS number 57808-65-8, is a highly effective halogenated salicylanilide compound widely utilized in the veterinary pharmaceutical industry. As a potent antiparasitic agent, it plays a pivotal role in maintaining the health and productivity of livestock worldwide. Its primary mode of action involves uncoupling oxidative phosphorylation in parasites, a critical metabolic process, which ultimately inhibits ATP synthesis. This disruption starves the parasites of energy, leading to their demise.

The efficacy of Closantel extends across a broad spectrum of internal and external parasites, making it an invaluable tool for veterinarians and animal husbandry professionals. In cattle and sheep, it demonstrates significant activity against major trematodes such as Fasciola hepatica and Fasciola gigantica, commonly known as liver flukes. Beyond flukes, Closantel is highly effective against various blood-sucking nematodes, including Haemonchus concortus, Haemonchus placei, Bunostomum phlebotomum, Oesophagostomum radiatum, and Strongyloides papillosus. For cattle, it is also indicated for the treatment and prevention of infestations by the larval stages of arthropods like Hypoderma bovis (cattle grub). In sheep, its utility expands to include other parasitic species such as Paramphistomum spp., Chabertia ovina, and Oestrus ovis (sheep nasal bot fly larvae).

The manufacturing of pharmaceutical-grade Closantel necessitates strict adherence to quality control standards. Reputable manufacturers ensure a purity level of typically 99%, ensuring its efficacy and safety for animal applications. This commitment to quality aligns with various international medicine grade standards, supporting its use in sophisticated veterinary formulations. Such high-quality raw materials are essential for producing injectable solutions and other dosage forms that deliver consistent and reliable therapeutic outcomes.

It is paramount to underscore the critical safety considerations associated with Closantel. While highly beneficial in veterinary applications, Closantel is strictly contraindicated for human use. Accidental ingestion, even in seemingly low dosages, has been documented to cause severe and irreversible adverse effects in humans, most notably leading to significant visual impairment or complete blindness due to direct toxic effects on the neurosensory retina and visual pathways. Other reported human toxicities include neurological symptoms, although these are less common with lower doses. Therefore, extreme caution must be exercised to prevent human exposure to this compound. Furthermore, its use in milk-producing animals intended for human consumption is restricted or prohibited during certain periods, including the dry period, the last trimester of pregnancy in heifers, and within one year prior to the first lambing in ewes, due to the potential for residue secretion in milk. Overdosing in animals can also lead to adverse effects such as reduced visibility, anorexia, lack of coordination, and general weakness, highlighting the importance of correct dosage and administration under veterinary supervision.

For pharmaceutical companies and formulators seeking a reliable Closantel manufacturer or Closantel supplier, NINGBO INNO PHARMCHEM CO.,LTD. offers high-quality raw materials. As a dedicated provider of pharmaceutical chemicals, NINGBO INNO PHARMCHEM CO.,LTD. ensures its Closantel product meets rigorous medicine grade specifications, offering a dependable source for your production needs. Prospective clients interested in the Closantel price or looking to buy Closantel can easily initiate a Closantel purchase inquiry to discuss bulk supply options and competitive pricing directly with the sales team. Partnering with a trusted supplier is key to ensuring the quality and safety of your veterinary pharmaceutical products.