In the intricate landscape of pharmaceutical synthesis, certain chemical intermediates stand out for their pivotal role in the production of life-changing medications. Among these is 3-(2-Aminoethyl)-N-methyl-1H-indole-5-methanesulfonamide, also widely known by its more common synonym, Didesmethyl Sumatriptan. This compound, identified by its CAS.NO: 88919-22-6, is an indispensable building block in the creation of Sumatriptan and Sumatriptan succinate, two critical active pharmaceutical ingredients (APIs) used globally in the treatment of migraine headaches.

The chemical identity of this compound is defined by its molecular formula, C12H17N3O2S, resulting in a molecular weight of 267.34700. Beyond Didesmethyl Sumatriptan, it is recognized by various other synonyms including Sumatriptan EP Impurity E, 2-[5-[(methylamino)sulphonyl]methyl]-1H-indol-3-yl]ethanamine, and 1H-Indole-5-methanesulfonamide, 3-(2-aminoethyl)-N-methyl. These names reflect its structural characteristics and its association with the Sumatriptan family of compounds, often appearing as an impurity or a synthetic precursor in the manufacturing process of the final drug.

Understanding the physical and chemical properties of 3-(2-Aminoethyl)-N-methyl-1H-indole-5-methanesulfonamide is crucial for its handling, storage, and application in chemical synthesis. It exhibits a density of 1.394g/cm3. Its thermal properties are also well-defined, with a boiling point recorded at 523.772ºC at 760 mmHg, a melting point ranging from 151-154ºC, and a flash point of 270.568ºC. The refractive index is measured at 1.65, contributing to its overall characterization. These properties ensure that the compound behaves predictably under various processing conditions, a key factor in pharmaceutical production where consistency is paramount.

From a commercial and quality control perspective, the specifications of this intermediate are stringent. Typically, 3-(2-Aminoethyl)-N-methyl-1H-indole-5-methanesulfonamide presents as a beige powder. Purity is a critical parameter for pharmaceutical intermediates, and for this compound, it is consistently maintained at ≥98%. This high level of purity is essential to prevent contamination and ensure the efficacy and safety of the final drug product, Sumatriptan. Packaging usually involves 25kg cardboard drums, though arrangements can be made to meet specific customer requirements, emphasizing flexibility in supply chain logistics.

The primary and most significant application of 3-(2-Aminoethyl)-N-methyl-1H-indole-5-methanesulfonamide is its role as an intermediate in the synthesis of Sumatriptan (CAS: 103628-46-2) and Sumatriptan succinate (CAS: 103628-48-4). Sumatriptan belongs to a class of drugs known as triptans, which are specifically designed to treat acute migraine attacks and cluster headaches. It works by narrowing blood vessels in the brain and affecting certain nerves, thereby alleviating the severe pain, nausea, and sensitivity to light and sound associated with these debilitating conditions. The reliability and quality of this intermediate directly impact the successful synthesis and ultimate effectiveness of the final Sumatriptan product, making its sourcing a critical decision for pharmaceutical companies.

Proper storage of 3-(2-Aminoethyl)-N-methyl-1H-indole-5-methanesulfonamide is vital to maintain its stability and purity over time. It should be stored in a refrigerator, specifically in a cool and dry, well-closed container. Protecting the compound from moisture and strong light/heat is imperative to prevent degradation and ensure its long-term viability as a high-quality intermediate for pharmaceutical manufacturing processes. Adherence to these storage guidelines ensures that the product retains its specified chemical integrity until it is ready for use.

For pharmaceutical companies and research institutions, sourcing high-quality intermediates like Didesmethyl Sumatriptan is a strategic decision. Choosing a reputable and experienced manufacturer or a specialized supplier is paramount to ensuring the success of complex synthesis pathways. Factors such as consistent product availability, adherence to stringent quality standards, and comprehensive documentation are critical considerations. We strive to offer a competitive price while upholding the highest standards of purity and reliability, recognizing that the integrity of our products directly contributes to the safety and efficacy of the medicines they enable. When you are ready to buy or purchase this essential pharmaceutical intermediate, selecting a partner committed to excellence ensures that your production processes run smoothly and efficiently, from initial synthesis to final drug formulation.