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At NINGBO INNO PHARMCHEM CO.,LTD., we specialize in providing essential chemical reagents that drive progress in synthetic chemistry, and Trimethylsilylacetylene (CAS 1066-54-2) is a prime example. Its participation in palladium-catalyzed cross-coupling reactions has revolutionized how chemists introduce ethynyl groups into complex molecules, making it a cornerstone for many synthetic strategies.
The versatility of Trimethylsilylacetylene in palladium(0)-catalyzed coupling reactions with aryl and vinyl halides and triflates is a testament to its importance. This process allows for the efficient and selective formation of carbon-carbon bonds, a fundamental transformation in the synthesis of pharmaceuticals, agrochemicals, and advanced materials. Understanding the trimethylsilylacetylene chemical properties is crucial for optimizing these coupling reactions.
The mechanism often involves the deprotection of the silyl group, liberating the terminal alkyne for participation in the catalytic cycle. This makes Trimethylsilylacetylene an ideal silane protected acetylene, offering a stable precursor that can be selectively activated when needed. The ease of handling this liquid reagent, compared to gaseous acetylene, further enhances its appeal in laboratories and industrial settings seeking to buy Trimethylsilylacetylene for high-yield synthesis.
Moreover, Trimethylsilylacetylene also serves as a substrate for nickel-catalyzed cross-coupling with benzonitriles, expanding its applicability in catalytic transformations. This dual role in different catalytic systems highlights its broad utility and the ongoing research into its reaction pathways, including the study of trimethylsilylacetylene synthesis routes that ensure high purity.
NINGBO INNO PHARMCHEM CO.,LTD. is proud to supply Trimethylsilylacetylene of exceptional quality, ensuring that your palladium-catalyzed cross-coupling reactions proceed with maximum efficiency and desired outcomes. Trust us for your supply of this vital organic synthesis building blocks and advance your research and production with confidence.
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1. 20 years of R&D, manufacturing and sales experience, serving customers in 60 countries and regions around the world;
2. Own R&D laboratory, pilot platform and large-scale production workshop, which can meet the audit requirements of global customers;
3. We can satisfy customers' perfect transition from small scale lab requirements (gram level) to commercialization requirements (hundred tons level).
A: We don't have Minimum Order Quantity, exact quantity should be provided before quotation for us to calculate the exact cost.
A: We don't provide free samples due to lots of request and expensive international courier's cost, we can deduct the sample charge after commercial order placed.
A: Our payment terms: Small or sample order: T/T IN ADVANCE. Commercial order: First order should be by T/T IN ADVANCE or L/C at sight, and following orders T/T 30~90days is acceptable subject to approval of credit application.
