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Exploring (S)-(-)-2,2'-Dimethoxy-1,1'-binaphthalene: A Key Chiral Ligand

In the expansive realm of advanced chemistry, certain compounds stand out for their exceptional utility and versatility. Among these, (S)-(-)-2,2'-Dimethoxy-1,1'-binaphthalene, identified by its CAS Registry Number 75640-87-8, holds a prominent position. This distinguished chiral compound is celebrated for its unique structural characteristics, which enable it to facilitate highly selective reactions across various chemical processes, making it indispensable in modern scientific and industrial applications. Its significance stems from its ability to precisely control stereochemistry, a critical factor in the synthesis of complex organic molecules.


Chemically, (S)-(-)-2,2'-Dimethoxy-1,1'-binaphthalene presents as a white to off-white crystalline powder, indicative of its high purity and stable form. It possesses a molecular formula of C22H18O2 and a molecular weight of 314.38 g/mol. Key physical properties include a melting point typically ranging from 227 to 232 °C. Furthermore, its optical activity, a defining feature of chiral compounds, is notably strong, with an alpha value of approximately -52° (c=1, THF) or -70° to -75° (C=1.2 in THF), underscoring its pronounced enantiomeric purity. This compound exhibits insolubility in water, which is a common characteristic for many organic compounds of its structure, influencing its handling and application in non-aqueous environments.


The primary and most impactful application of (S)-(-)-2,2'-Dimethoxy-1,1'-binaphthalene lies within the field of asymmetric synthesis. It serves as an incredibly effective chiral ligand in a multitude of transition metal-catalyzed reactions. This role is paramount in the pharmaceutical and agrochemical industries, where the production of specific enantiomers is not just preferred but often mandatory for biological activity and safety. By guiding reactions to produce one specific stereoisomer over another, this compound ensures the high precision and efficiency required for synthesizing complex active pharmaceutical ingredients and agrochemical compounds. Its unique configuration allows for the fine-tuning of catalytic processes, leading to superior yields and enantiomeric excess.


Beyond its pivotal role in asymmetric catalysis, (S)-(-)-2,2'-Dimethoxy-1,1'-binaphthalene demonstrates remarkable utility across several other high-tech sectors. In the burgeoning field of organic electronics, it is employed in the development of organic light-emitting diodes (OLEDs), contributing to enhanced efficiency and vibrant color purity in displays. Within material science, this compound is incorporated into polymer matrices, where it improves mechanical properties and thermal stability, paving the way for advanced high-performance materials. Its luminescent properties also make it valuable in biochemical research, acting as a fluorescent probe to track intricate molecular interactions and dynamics in real-time. Moreover, its distinct chiral structure is highly beneficial in drug development, aiding scientists in designing novel drug candidates that can precisely target specific biological pathways, thereby enhancing therapeutic efficacy and reducing side effects.


As a leading manufacturer and supplier of high-quality chemical intermediates, NINGBO INNO PHARMCHEM CO.,LTD. is dedicated to providing superior (S)-(-)-2,2'-Dimethoxy-1,1'-binaphthalene. We ensure rigorous quality control and efficient production processes, adhering to the highest industry standards. For those looking to buy this essential compound, NINGBO INNO PHARMCHEM CO.,LTD. offers competitive price and reliable worldwide shipping options. We invite you to purchase directly from a trusted source, ensuring you receive a product of unmatched purity and performance for your research and industrial needs. Our commitment is to deliver excellence, supporting innovation and success in your critical chemical applications.

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