Isoxadifen-ethyl (CAS 163520-33-0) stands as a critical compound in modern agriculture, primarily recognized for its indispensable role as a herbicide safener. In the dynamic field of crop protection, preventing unintended damage to valuable crops while effectively combating stubborn weeds is paramount. Isoxadifen-ethyl addresses this challenge by acting as an antidote, significantly reducing or even eliminating the phytotoxic effects that certain herbicides might otherwise impose on sensitive crops, particularly in maize fields.

Chemically, Isoxadifen-ethyl is identified by its Chemical Abstracts Service (CAS) number 163520-33-0. It possesses a molecular formula of C18H17NO3 and a molecular weight of 295.33. Typically presenting as a white crystalline powder, this compound is distinguished by its high purity, often exceeding 98%. Its physical and chemical properties contribute to its stability and efficacy in agricultural formulations. Key characteristics include a melting point of 87-88 °C, a boiling point estimated around 407.7 °C at 760 mmHg, and a density of approximately 1.15 g/cm3. The flash point is noted at 166.8 °C, with a very low vapor pressure of 7.43E-07 mmHg at 25°C, ensuring safe handling under recommended conditions.

The primary application of Isoxadifen-ethyl is as an auxiliary agent designed to protect crops. Its mechanism involves enhancing the innate drug resistance of crops to herbicides. This protective action is particularly beneficial in corn fields, where it is extensively used to prevent both annual and perennial weeds. By safeguarding the crop, Isoxadifen-ethyl allows for the use of more potent and effective herbicides, thereby broadening the spectrum of weeds that can be controlled and enhancing the overall effectiveness of weed management strategies. It is notably effective when used in conjunction with herbicides such as fenoxaprop-P-ethyl and iodosulfuron-methyl-sodium, optimizing their performance without harming the cultivated plant.

The strategic deployment of safeners like Isoxadifen-ethyl is a cornerstone of sustainable agricultural practices. It enables farmers to achieve superior weed control, leading to healthier crops and increased yields, while simultaneously reducing the risk of crop injury. This translates into economic benefits for growers and contributes to food security by ensuring more reliable harvests. Proper storage is crucial to maintain its integrity and effectiveness; it should be stored in a cool, dry, and well-ventilated area, away from sources of fire, heat, direct light, strong acids, and food materials.

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