NINGBO INNO PHARMCHEM CO.,LTD. is proud to showcase its premier pharmaceutical-grade product, Desmopressin Acetate (CAS: 16789-98-3), a synthetic peptide that represents a cornerstone in the management of several challenging medical conditions. As a modified analogue of the natural human hormone vasopressin, Desmopressin Acetate is engineered for enhanced efficacy and a more favorable safety profile. Our commitment to excellence ensures that we provide this vital compound at over 99% purity, meeting the stringent USP/BP/EP standards required by the global pharmaceutical industry.

Desmopressin, often referred to by its chemical designation 1-deamino-8-D-arginine vasopressin (DDAVP), is a testament to the power of targeted molecular modification. The natural hormone vasopressin has two primary effects: an antidiuretic (water-retaining) effect and a vasopressor (blood vessel-constricting) effect. While essential, the vasopressor action can be an undesirable side effect in many clinical contexts. Scientists ingeniously modified the vasopressin structure to create Desmopressin, which dramatically enhances the antidiuretic properties while minimizing the pressor effects. The result is a highly selective and potent therapeutic agent with an antidiuretic-to-pressor activity ratio thousands of times greater than that of its natural counterpart.

Mechanism of Action: Precision at the Molecular Level
The primary mechanism of Desmopressin Acetate revolves around its function as a selective agonist for the vasopressin V2 receptors. These receptors are predominantly located on the basolateral membrane of the collecting ducts in the kidneys.
When Desmopressin binds to these V2 receptors, it initiates a G-protein-coupled signaling cascade, leading to the activation of adenylate cyclase. This enzyme, in turn, increases the intracellular concentration of cyclic AMP (cAMP). The elevated cAMP levels activate Protein Kinase A (PKA), which then phosphorylates specific proteins that promote the insertion of aquaporin-2 (AQP2) water channels into the apical membrane of the collecting duct cells. This strategic placement of water channels dramatically increases the membrane's permeability to water, allowing for greater reabsorption of water from the urine back into the bloodstream. The direct consequence is a reduction in urine volume and an increase in urine osmolality, effectively conserving body water.

Diverse Therapeutic Applications
The powerful antidiuretic effect of Desmopressin Acetate makes it the drug of choice for several conditions:

1. Central Diabetes Insipidus (CDI): This condition arises from a deficiency of vasopressin, leading to severe polyuria (excessive urination) and polydipsia (excessive thirst). Patients can excrete many liters of dilute urine per day, leading to life-threatening dehydration. Desmopressin Acetate provides effective hormone replacement therapy, controlling symptoms by reducing urine output and allowing patients to lead a normal life. It is indicated for managing the temporary polyuria and polydipsia that can follow head trauma or pituitary surgery.

2. Primary Nocturnal Enuresis (PNE): Commonly known as bedwetting, PNE is a distressing condition for children and their families. Desmopressin works by reducing nighttime urine production to a volume that the bladder can hold, leading to dry nights. Its efficacy and safety have made it a standard treatment for PNE when behavioral therapies are insufficient.

3. Nocturia in Adults: The need to wake up one or more times during the night to urinate can severely disrupt sleep and impact quality of life. Desmopressin is approved for treating nocturia caused by nocturnal polyuria, helping to consolidate sleep by reducing urine production overnight.

4. Hemostatic Effects: Beyond its renal effects, Desmopressin Acetate has a crucial role in hematology. It stimulates the release of von Willebrand Factor (vWF) and Factor VIII from their storage sites in the endothelial cells lining blood vessels. This transient increase in circulating levels of these essential clotting factors can be sufficient to ensure hemostasis during minor surgical procedures or to control bleeding episodes in patients with mild Hemophilia A and most subtypes of Type 1 von Willebrand disease.

Quality and Reliability by NINGBO INNO PHARMCHEM CO.,LTD.
At NINGBO INNO PHARMCHEM CO.,LTD., we understand that the integrity of an active pharmaceutical ingredient (API) is paramount. Our Desmopressin Acetate is produced as a sterile, white to off-white lyophilized powder, ensuring stability and ease of reconstitution. We employ rigorous quality control protocols at every stage of production, from raw material sourcing to final product packaging. Our state-of-the-art facilities and adherence to Good Manufacturing Practices (GMP) guarantee a product that is not only pure but also consistently reliable and safe.

When searching for a Desmopressin Acetate manufacturer, it is crucial to partner with a company that prioritizes quality. As a leading supplier in the chemical and pharmaceutical sector, we provide comprehensive documentation and support to our clients. For those looking to buy or purchase this essential peptide, we offer competitive and transparent price points, especially for bulk orders. Choosing to purchase from a reputable source like NINGBO INNO PHARMCHEM CO.,LTD. ensures that you receive a high-quality product that meets all regulatory specifications. We invite you to inquire about our Desmopressin Acetate to see how our commitment to quality can benefit your needs.