NINGBO INNO PHARMCHEM CO.,LTD. is at the forefront of producing high-quality active pharmaceutical ingredients (APIs), and we are proud to spotlight one of the critical peptides in our portfolio: Terlipressin (CAS 14636-12-5). This potent synthetic analogue of vasopressin is indispensable in emergency and critical care medicine, offering a lifeline to patients with severe complications of advanced liver disease.

Terlipressin's primary applications are in the management of hepatorenal syndrome (HRS) and acute esophageal variceal bleeding, two life-threatening conditions. Understanding its function and the importance of its purity is crucial for healthcare providers and pharmaceutical formulators. As a dedicated manufacturer, we ensure our Terlipressin meets the highest global standards, providing a reliable foundation for life-saving therapies.

Understanding Terlipressin and Its Mechanism of Action

Terlipressin is a prodrug of lysine vasopressin. After administration, it is gradually cleaved by endothelial peptidases in the body to release the active molecule, lysine vasopressin. This slow-release mechanism provides a longer duration of action and a more stable physiological effect compared to administering vasopressin directly, which enhances its therapeutic window and safety profile.

The primary mechanism of action involves its potent vasoconstrictive effects, mediated through the activation of V1 receptors on vascular smooth muscle cells. In patients with cirrhosis and portal hypertension, the splanchnic (abdominal) blood vessels become excessively dilated, leading to a cascade of problems. This includes reduced overall systemic blood pressure and decreased effective blood volume, which in turn leads to severe renal vasoconstriction and the development of hepatorenal syndrome.

By selectively constricting the splanchnic vasculature, Terlipressin helps to:
1. Reduce Portal Pressure: It significantly lowers the dangerously high blood pressure in the portal vein system. This is the direct cause of esophageal varices—swollen veins in the esophagus that are prone to rupture and catastrophic bleeding.
2. Increase Mean Arterial Pressure (MAP): By redirecting blood from the splanchnic circulation back into the systemic circulation, Terlipressin raises the overall blood pressure.
3. Improve Renal Perfusion: The increase in MAP and effective arterial blood volume helps to counteract the renal vasoconstriction characteristic of HRS, thereby improving kidney function and increasing glomerular filtration rate.

Clinical Significance in Hepatorenal Syndrome (HRS) and Variceal Bleeding

Hepatorenal syndrome is a severe complication of end-stage liver disease, characterized by a rapid decline in kidney function. Without intervention, it has an extremely high mortality rate. Terlipressin, often administered with albumin, is considered a first-line treatment and is the only therapy that has consistently shown a survival benefit. By reversing the underlying circulatory dysfunction, it can improve kidney function enough to serve as a vital bridge to liver transplantation.

In cases of acute variceal bleeding, Terlipressin is a cornerstone of pharmacological therapy. Its ability to reduce portal blood flow and pressure helps to control active bleeding and prevent re-bleeding, stabilizing the patient so that endoscopic procedures can be performed safely and effectively. Its use in this setting has been shown to reduce treatment failure and improve mortality rates.

Commitment to Quality: Our Terlipressin Specifications

At NINGBO INNO PHARMCHEM CO.,LTD., we understand that the efficacy and safety of an API like Terlipressin are directly linked to its purity and quality. We adhere to rigorous manufacturing processes and quality control protocols to produce a product that our clients can trust. Our Terlipressin is characterized by its exceptional quality, as detailed in our specifications:

• Appearance: A White or off-white powder, ensuring uniformity and quality.
• Purity (HPLC): ≥98.0%, with our typical batches achieving levels like 99.06%. This high level of purity minimizes the risk of adverse reactions from impurities.
• Solubility: Readily soluble in water, which is essential for its preparation as an injectable solution.
• Related Substances: We strictly control impurities, with any individual impurity kept at ≤0.5% and total impurities at ≤2.0%, ensuring a clean and safe product profile.
• Water Content: Maintained at ≤5.0% to ensure stability and accurate dosing.
• Residual Solvents: Kept well below established safety limits (e.g., Acetonitrile ≤410ppm) to guarantee patient safety.

As a premier manufacturer and supplier of specialized peptides, NINGBO INNO PHARMCHEM CO.,LTD. is dedicated to supporting the pharmaceutical industry with reliable and high-grade APIs. Our commitment extends from sourcing raw materials to final packaging, all conducted under strict GMP guidelines. We provide comprehensive documentation and support to our partners to facilitate their formulation and regulatory processes.

For those looking to buy or purchase Terlipressin, it is essential to partner with a trusted source. The quality of the API is not a point for compromise when patient lives are at stake. We offer our high-purity Terlipressin at a competitive price, ensuring that this critical medication can be made accessible. We invite pharmaceutical companies, research institutions, and compounding pharmacies to connect with us to learn more about our Terlipressin and how we can meet your specific needs. Our team is ready to provide samples and detailed specifications to prove the superior quality of our product. Choose NINGBO INNO PHARMCHEM CO.,LTD. for a partnership built on quality, reliability, and a shared mission to improve patient outcomes.