Fexofenadine Hydrochloride, identified by its CAS number 153439-40-8, stands as a significant active pharmaceutical ingredient (API) in the modern landscape of allergy management. As a second-generation antihistamine, it represents an advancement over earlier compounds by offering potent relief from allergic symptoms with a reduced propensity for central nervous system side effects, such as drowsiness. This distinct advantage has made it a preferred choice for pharmaceutical manufacturers developing formulations for a broad range of patients, including adults, children, and the elderly.

Derived from terfenadine, Fexofenadine Hydrochloride functions primarily as a selective peripheral H1 receptor antagonist. This mechanism means it effectively blocks the action of histamine, a key mediator released during allergic reactions, particularly targeting receptors located outside the brain. Its high affinity for these peripheral receptors, coupled with its limited ability to cross the blood-brain barrier, accounts for its efficacy in controlling allergy symptoms without significantly impairing cognitive function or causing sedation. This makes it suitable for daily use, allowing individuals to manage their allergies without disruption to their routines.

The primary applications for Fexofenadine Hydrochloride powder revolve around treating conditions mediated by histamine release. It is widely used for the symptomatic relief of seasonal allergic rhinitis, commonly known as hay fever. Symptoms addressed include repeated sneezing, a runny nose (rhinorrhea), itchy or watery eyes, and itching of the nose, palate, or throat. These uncomfortable manifestations of seasonal allergies can significantly impact quality of life, and Fexofenadine Hydrochloride provides effective alleviation. Beyond seasonal allergies, it is also indicated for the treatment of chronic idiopathic urticaria, a condition characterized by the recurrent appearance of hives or welts on the skin without a clear identifiable cause. In this context, Fexofenadine Hydrochloride helps to reduce the number of hives and the severity of itching associated with the condition.

As a pharmaceutical raw material, Fexofenadine Hydrochloride is typically supplied as a white powder. Achieving high levels of purity, often exceeding 99% as verified by analytical methods like High-Performance Liquid Chromatography (HPLC), is critical for ensuring the safety and efficacy of finished drug products. The molecular formula for Fexofenadine Hydrochloride is C32H40ClNO4, with a molecular weight of approximately 538.13. Its melting point is reported to be within the range of 148-150°C. Adherence to stringent quality standards, including Good Manufacturing Practices (GMP), and meeting pharmacopoeial requirements such as those outlined in USP or BP, are essential for APIs intended for human use. Manufacturers sourcing this material require confidence in its consistency, purity, and compliance with regulatory guidelines.

The benefits of using Fexofenadine Hydrochloride as an API extend beyond its therapeutic profile. Its well-established safety record and efficacy are supported by extensive clinical data. The market demand for effective, non-drowsy antihistamines continues to grow globally, driven by increasing prevalence of allergic diseases and greater patient awareness. This creates a consistent need for reliable sources of high-quality Fexofenadine Hydrochloride powder for pharmaceutical production. Companies formulating solid dosage forms like tablets or capsules require an API with consistent physical properties, such as particle size distribution and flowability, to ensure efficient manufacturing processes and uniform finished products.

For pharmaceutical companies seeking a reliable source for this essential API, partnering with an experienced manufacturer is crucial. A reputable supplier will not only provide material meeting rigorous quality standards but also offer necessary documentation and support for regulatory submissions. Understanding the factors that influence the price of Fexofenadine Hydrochloride powder is also important for procurement decisions, as it can vary based on purity, quantity, manufacturing process, and market conditions. When considering where to buy Fexofenadine HCl, evaluating potential supplier options is key, focusing on their track record, quality control processes, and capacity to ensure a stable supply chain. Making the decision to purchase high-purity Fexofenadine Hydrochloride requires careful due diligence to secure a consistent and compliant raw material for producing safe and effective allergy medications.