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Understanding how drugs are absorbed, distributed, metabolized, and excreted (ADME) is fundamental to pharmaceutical research and drug development. A key aspect of drug disposition is the role of membrane transporters, particularly efflux pumps like P-glycoprotein (P-gp) and Breast Cancer Resistance Protein (BCRP). These transporters can significantly influence drug efficacy and safety. Elacridar, also known by codes like GG918, serves as an invaluable research tool for investigating these complex mechanisms.
Elacridar, with CAS number 143664-11-3, is a well-characterized, potent inhibitor of both P-gp and BCRP. Its specificity and efficacy make it a preferred choice for researchers aiming to elucidate the impact of these transporters on drug pharmacokinetics. By using Elacridar, scientists can effectively block the efflux activity of P-gp and BCRP, allowing them to observe the true absorption and distribution profiles of drug candidates without the confounding influence of these pumps. This is particularly important when evaluating drug candidates that are substrates for these transporters.
For research institutions and pharmaceutical companies, obtaining high-quality Elacridar is crucial for accurate and reproducible studies. As a dedicated supplier of research chemicals, we provide Elacridar manufactured to stringent quality standards. This ensures that you receive a reliable product that will yield meaningful results in your drug transport assays. Purchasing Elacridar from us means you are partnering with a manufacturer committed to supporting scientific advancement through high-purity compounds.
The applications of Elacridar in transport studies are broad. It is used to: 1) Determine if a drug candidate is a substrate for P-gp or BCRP by observing the effect of Elacridar on its cellular accumulation. 2) Investigate the role of P-gp and BCRP in specific tissues or organs, such as the blood-brain barrier or the liver. 3) Evaluate potential drug-drug interactions where one drug might inhibit or induce these transporters. If your research involves understanding these critical transport mechanisms, we encourage you to buy Elacridar and explore its utility. Contact us for competitive pricing and reliable sourcing for your research needs.
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1. 20 years of R&D, manufacturing and sales experience, serving customers in 60 countries and regions around the world;
2. Own R&D laboratory, pilot platform and large-scale production workshop, which can meet the audit requirements of global customers;
3. We can satisfy customers' perfect transition from small scale lab requirements (gram level) to commercialization requirements (hundred tons level).
A: We don't have Minimum Order Quantity, exact quantity should be provided before quotation for us to calculate the exact cost.
A: We don't provide free samples due to lots of request and expensive international courier's cost, we can deduct the sample charge after commercial order placed.
A: Our payment terms: Small or sample order: T/T IN ADVANCE. Commercial order: First order should be by T/T IN ADVANCE or L/C at sight, and following orders T/T 30~90days is acceptable subject to approval of credit application.
