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L-Histidine Methyl Ester Dihydrochloride: A Versatile Amino Acid Derivative

L-Histidine methyl ester dihydrochloride, identified by its CAS number 7389-87-9, stands as a pivotal compound in the realm of biochemical and pharmaceutical sciences. This high-purity amino acid derivative is widely recognized for its diverse applications, ranging from fundamental research to advanced drug formulation. Its unique chemical structure, characterized by the molecular formula C7H13Cl2N3O2 and a molecular weight of 242.1, imbues it with properties essential for numerous scientific and industrial processes.


As a white powder, L-Histidine methyl ester dihydrochloride exhibits excellent purity, typically at or exceeding 97-99% (HPLC). Its melting point is observed to be approximately 198-207 °C, often with decomposition. For optimal preservation of its integrity and effectiveness, it is recommended to store this hygroscopic compound under an inert atmosphere, at temperatures between 0-8°C, meticulously protected from moisture. Its solubility in common laboratory solvents such as dimethyl sulfoxide (DMSO), methanol, and water further enhances its versatility and ease of use in various experimental setups.


One of the primary applications of L-Histidine methyl ester dihydrochloride lies in the synthesis of optically pure L-(+)-ergothioneine, a naturally occurring amino acid derivative with significant antioxidant properties. Beyond this specific synthesis, its role as a precursor in the broader synthesis of histidine, an essential amino acid vital for protein synthesis and enzyme function, is invaluable. Researchers frequently leverage this compound in biochemical investigations, particularly in studies related to metabolic pathways and enzyme kinetics. Its ability to act as a buffer in biological systems makes it an indispensable component in cell culture media, providing crucial nutritional support for optimal cell proliferation and facilitating fermentation processes.


The utility of L-Histidine methyl ester dihydrochloride extends significantly into the pharmaceutical industry. It is a preferred choice for the formulation of various drug compounds due to its capacity to enhance bioavailability and facilitate targeted drug delivery. The compound aids in the creation of histidine-rich peptides, which are instrumental in improving the stability and efficacy of therapeutic agents. Furthermore, its potential applications in nutrition and dietary supplements are being explored, with research indicating its role in supporting muscle recovery and overall metabolic health. Studies investigating its involvement in neurotransmitter synthesis also hold promise for insights into neurological disorders.


For laboratories and industries seeking a reliable and high-quality source of this essential chemical, we pride ourselves on being a trusted manufacturer and supplier of L-Histidine methyl ester dihydrochloride. Our commitment to stringent quality control ensures that every batch meets the highest purity standards required for demanding applications. We offer competitive price options and flexible packaging to meet diverse needs, whether for small-scale research or large-volume industrial production. To inquire about our product specifications, current availability, or to buy / purchase L-Histidine methyl ester dihydrochloride, please contact our dedicated sales team. We are ready to provide detailed information and assist with your procurement needs, ensuring a seamless experience for all your scientific and industrial endeavors.

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