Lidocaine Base, a highly valued active pharmaceutical ingredient (API) with CAS number 137-58-6, stands as a cornerstone in modern medicine for its remarkable anesthetic and antiarrhythmic properties. NINGBO INNO PHARMCHEM CO.,LTD. is proud to present this high-purity compound, essential for a wide array of pharmaceutical applications globally.

Known chemically as 2-(diethylamino)-N-(2,6-dimethylphenyl)acetamide, Lidocaine Base is the non-ionized, 'free base' form of lidocaine. This chemical characteristic is fundamental to its efficacy, particularly in topical applications. Unlike its salt form, Lidocaine Base is characterized by its limited water solubility but excellent solubility in organic solvents like ethyl alcohol and various oils. This property makes it exceptionally suitable for formulations intended to penetrate biological membranes, such as skin, where a non-ionized form is more readily absorbed.

The primary medical application of Lidocaine Base lies in its role as a local anesthetic. It functions by inhibiting sodium influx through voltage-gated sodium channels in neuronal cell membranes, effectively blocking nerve signal conduction. This mechanism provides rapid and profound numbing, making it indispensable in various medical and dental procedures. It is extensively used in creams, ointments, gels, and transdermal patches for surface anesthesia. These formulations are particularly effective for alleviating localized pain, such as from neuropathic conditions, skin graft donor sites, or for providing pre-procedural numbing prior to minor surgical interventions or aesthetic treatments. Its ability to penetrate the skin efficiently makes it a preferred choice for such topical preparations, delivering targeted pain relief where it’s needed most.

Beyond its anesthetic capabilities, Lidocaine Base also possesses significant antiarrhythmic properties. Administered intravenously, it is classified as a Class Ib antiarrhythmic drug, employed in the treatment of ventricular arrhythmias, especially in situations where other treatments may be contraindicated or unavailable. Furthermore, its therapeutic scope extends to specialized uses like the management of certain types of epilepsy, where it can act as a second-line treatment for neonatal seizures. It is also explored in chronic pain management as an opiate-sparing technique and even as an inhaled cough suppressor to enhance patient comfort during procedures like intubation. Its application in emergency situations, such as jellyfish stings, helps to numb the affected area and prevent further venom discharge.

The quality and purity of Lidocaine Base are paramount for its pharmaceutical applications. NINGBO INNO PHARMCHEM CO.,LTD. ensures that its Lidocaine Base meets the stringent requirements of international pharmacopoeias, including the European Pharmacopoeia (Ph. Eur.), United States Pharmacopeia (USP-NF), and Japanese Pharmacopoeia (JP). Our commitment to quality guarantees a product with exceptional purity, typically 99% or higher, and consistent performance, enabling our clients to develop safe and effective pharmaceutical formulations.

As a trusted manufacturer and supplier of Lidocaine Base, NINGBO INNO PHARMCHEM CO.,LTD. maintains rigorous quality control standards throughout the production process. We strive to offer competitive price options, ensuring accessibility for pharmaceutical companies and research institutions worldwide. For those seeking to buy or purchase premium Lidocaine Base, our comprehensive understanding of its chemical and pharmacological profile, combined with our robust supply chain, positions us as an ideal partner. We are dedicated to supporting advancements in pain relief and therapeutic treatments through the consistent provision of high-grade APIs.