Custom Manufacturing, Project Outsourcing, your Trusted Partner from China
NINGBO INNO PHARMCHEM CO.,LTD. is dedicated to unraveling the intricate molecular mechanisms that underpin the diverse pharmacological effects of Matrine. Understanding how this natural alkaloid interacts at a cellular and molecular level is key to optimizing its therapeutic applications and developing more targeted treatments.
Matrine's action in cardiovascular protection, for example, is linked to its modulation of various signaling pathways. In combating atherosclerosis, it influences pathways such as JAK/STAT3 and NF-κB/MAPK, affecting inflammation and cell adhesion. For hypertension, it impacts α-adrenoceptor activation, cell cycle regulation in pulmonary artery smooth muscle cells, and the RhoA/Rock1 pathway related to myocardial fibrosis.
In the context of anti-cancer activity, Matrine targets a multitude of pathways crucial for tumor growth and survival. It can inhibit the PI3K/Akt/mTOR pathway, which is often hyperactivated in cancer cells, leading to cell cycle arrest and apoptosis. Matrine also influences pathways like Wnt/β-Catenin, ERK, and regulates the expression of key proteins and microRNAs involved in cell proliferation, metastasis, and drug resistance.
Furthermore, Matrine's anti-inflammatory effects are largely attributed to its ability to inhibit the NF-κB signaling pathway, thereby reducing the production of pro-inflammatory mediators. Its antibacterial and antiviral actions involve mechanisms that can disrupt bacterial cell membranes or interfere with viral replication processes.
While research has elucidated many of Matrine's mechanisms, there are still areas that require further exploration. Continued investigation into its precise molecular targets and downstream effects will undoubtedly pave the way for more refined and effective therapeutic strategies. NINGBO INNO PHARMCHEM CO.,LTD. is committed to this pursuit, aiming to bridge the gap between traditional knowledge and modern scientific understanding of natural compounds like Matrine.
Manufacturing Facilities
Professional Export Experience
to Global Customers
1. 20 years of R&D, manufacturing and sales experience, serving customers in 60 countries and regions around the world;
2. Own R&D laboratory, pilot platform and large-scale production workshop, which can meet the audit requirements of global customers;
3. We can satisfy customers' perfect transition from small scale lab requirements (gram level) to commercialization requirements (hundred tons level).
A: We don't have Minimum Order Quantity, exact quantity should be provided before quotation for us to calculate the exact cost.
A: We don't provide free samples due to lots of request and expensive international courier's cost, we can deduct the sample charge after commercial order placed.
A: Our payment terms: Small or sample order: T/T IN ADVANCE. Commercial order: First order should be by T/T IN ADVANCE or L/C at sight, and following orders T/T 30~90days is acceptable subject to approval of credit application.
