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At NINGBO INNO PHARMCHEM CO.,LTD., we recognize that while Matrine possesses significant therapeutic potential, its practical application can be limited by factors such as bioavailability and dosage. Consequently, a major focus of our research involves exploring advanced synthesis and derivatization techniques to unlock the full potential of this natural alkaloid.
Traditional extraction methods for Matrine, including solvent, ultrasonic, and microwave-assisted extractions, have been refined for industrial and laboratory preparations. However, yields from natural sources can be variable. To address this, researchers have developed various total synthesis strategies. While these methods have advanced the availability of Matrine, ongoing efforts aim to optimize these routes for higher yields and more controlled reaction conditions, making synthesis more efficient and cost-effective.
A key area of advancement lies in the derivatization of Matrine. By strategically modifying its molecular structure, scientists aim to enhance its pharmacological properties. Common modification sites include the tertiary amine at the N-1 position, the D-ring lactam, and various carbon positions. Introducing lipophilic groups, nitrogen-containing heterocycles, or combining Matrine with other active compounds has shown promise in increasing its anti-cancer and anti-viral activities.
For instance, modifications at the N-1 position have led to derivatives with enhanced analgesic effects. Hydrolysis of the D-ring lactam and subsequent modifications have yielded compounds with improved anti-proliferative activity against cancer cells, sometimes surpassing the efficacy of Matrine itself. Similarly, alterations at the C-13, C-14, and C-15 positions have resulted in derivatives with superior anti-cancer, anti-bacterial, and anti-viral properties.
These ongoing innovations in Matrine synthesis and derivatization are crucial for developing next-generation therapeutics. NINGBO INNO PHARMCHEM CO.,LTD. is committed to these advancements, aiming to provide high-quality Matrine and its derivatives that meet the evolving needs of the pharmaceutical industry and contribute to improved patient health outcomes.
Manufacturing Facilities
Professional Export Experience
to Global Customers
1. 20 years of R&D, manufacturing and sales experience, serving customers in 60 countries and regions around the world;
2. Own R&D laboratory, pilot platform and large-scale production workshop, which can meet the audit requirements of global customers;
3. We can satisfy customers' perfect transition from small scale lab requirements (gram level) to commercialization requirements (hundred tons level).
A: We don't have Minimum Order Quantity, exact quantity should be provided before quotation for us to calculate the exact cost.
A: We don't provide free samples due to lots of request and expensive international courier's cost, we can deduct the sample charge after commercial order placed.
A: Our payment terms: Small or sample order: T/T IN ADVANCE. Commercial order: First order should be by T/T IN ADVANCE or L/C at sight, and following orders T/T 30~90days is acceptable subject to approval of credit application.
