Obesity and overweight continue to represent a growing global health crisis, impacting hundreds of millions worldwide and significantly increasing the risk of numerous chronic diseases, including type 2 diabetes, cardiovascular issues, and fatty liver disease. The urgent need for effective, safe, and sustainable long-term treatment options has driven significant advancements in pharmacological interventions. NINGBO INNO PHARMCHEM CO.,LTD. is proud to introduce Mazdutide, a groundbreaking therapeutic poised to transform chronic weight management.

Mazdutide, a first-in-class dual glucagon-like peptide-1 (GLP-1) and glucagon receptor (GCGR) agonist, offers a unique and powerful mechanism of action. As an analog of oxyntomodulin (OXM), it simultaneously activates both GLP-1 and glucagon receptors. GLP-1 receptor activation is well-known for promoting glucose-dependent insulin secretion, lowering blood glucose, and reducing appetite, leading to substantial weight loss. Complementing this, glucagon receptor activation enhances energy expenditure and improves hepatic fat metabolism. This dual agonism provides enhanced weight-loss efficacy, reduces visceral fat, and delivers comprehensive metabolic benefits, addressing multiple facets of obesity and its comorbidities.

The efficacy and safety of Mazdutide have been rigorously demonstrated through extensive clinical development. Key findings from a pivotal Phase 3 clinical study (GLORY-1), involving Chinese adults with overweight or obesity, confirmed its superior performance. At week 48, participants receiving Mazdutide showed remarkable mean percentage reductions in body weight: -12.0% for the 4 mg dose and -14.8% for the 6 mg dose, significantly outperforming the placebo group's -0.5%. Furthermore, a substantial proportion of individuals achieved clinically meaningful weight loss of 15% or more, with 37.0% in the 4 mg group and 50.6% in the 6 mg group reaching this target. Beyond weight reduction, Mazdutide also led to significant decreases in waist circumference and liver fat content, showcasing its profound impact on cardiometabolic health.

The comprehensive metabolic benefits of Mazdutide extend to improvements in various key health indicators. Clinical trials have consistently shown reductions in blood pressure, beneficial changes in lipid profiles (total cholesterol, LDL cholesterol, and triglycerides), and significant decreases in serum uric acid and liver enzymes. These improvements collectively contribute to mitigating the risks associated with obesity-related metabolic dysfunction. Additionally, Mazdutide has demonstrated positive effects on glucose metabolism, including improvements in HbA1c, fasting plasma glucose, fasting insulin levels, and insulin sensitivity, making it a valuable option for managing hyperglycemia in non-diabetic individuals with obesity.

Safety and tolerability are paramount for long-term chronic treatments. Mazdutide has shown a favorable safety profile, consistent with other GLP-1 class drugs. The most common adverse events reported were mild to moderate gastrointestinal symptoms such as diarrhea, nausea, and vomiting, which were generally dose-related, transient, and manageable. Importantly, the incidence of adverse events leading to treatment discontinuation was low, supporting the long-term adherence crucial for effective weight management. No new safety signals were observed, and no cases of pancreatitis or thyroid tumors were reported in the studies, providing further reassurance regarding its safety.

The recent approval of Mazdutide by China's National Medical Products Administration (NMPA) for chronic weight management marks a significant milestone. This approval positions Mazdutide as the world's first dual GCG/GLP-1 receptor agonist specifically sanctioned for weight loss, recognizing its innovative mechanism and robust clinical evidence. For those seeking an effective weight loss solution, NINGBO INNO PHARMCHEM CO.,LTD. is committed to ensuring the broad availability of this product. As a leading manufacturer and reliable supplier, we are dedicated to providing high-quality pharmaceutical products. For detailed product information, including specifics on how to buy or purchase Mazdutide, please contact our sales team to inquire about price and distribution channels. We are poised to meet the growing demand for advanced weight management therapies, offering a superior option for healthcare providers and patients alike.