Tetra-n-butylammonium iodide (TBAI), with its CAS No. 311-28-4, stands as a pivotal quaternary ammonium salt in the realm of modern chemistry. This highly versatile compound, also commonly known as Tetrabutylammonium iodide, is recognized for its distinctive chemical and physical properties that enable its wide array of applications across various industrial and research sectors.

TBAI typically appears as a white to cream crystalline powder. Its chemical formula is C16H36IN, and it possesses a molecular weight of 369.37 g/mol. The melting point of Tetra-n-butylammonium iodide ranges approximately from 141°C to 148°C. A notable characteristic is its solubility profile: it readily dissolves in polar solvents such as water, methanol, and acetonitrile, while being insoluble in non-polar solvents like benzene. This solubility behavior is critical for its function in diverse chemical environments.

One of the most significant applications of Tetra-n-butylammonium iodide lies in its role as a phase transfer catalyst (PTC). In chemical reactions involving reactants present in immiscible phases (e.g., aqueous and organic), TBAI facilitates the transfer of ionic species from one phase to another. This catalytic action significantly enhances reaction rates, improves yields, and simplifies synthetic procedures, making it an invaluable tool for chemists. Its large, hydrophobic tetra-n-butylammonium cation effectively escorts anions into the organic phase, allowing reactions to proceed efficiently under milder conditions.

Beyond its catalytic role, TBAI finds extensive use in various synthetic processes. In organic synthesis, it is employed as a catalyst for the protection of alcohols as benzyl ethers with benzyl bromide, a common and essential transformation. Furthermore, TBAI is instrumental in the preparation of novel quaternary amines, which are increasingly critical in the fight against drug-resistant bacteria as potential antibacterial agents. It also serves as a key component in the synthesis of phosphonium reversible inhibitors of cholinesterases, compounds with significant pharmaceutical interest.

The utility of Tetra-n-butylammonium iodide extends into electrochemistry, where it is frequently used in the development of ionic liquids and as an electrolyte in high-performance batteries. Its stable nature and good conductivity make it an ideal choice for such demanding applications. In analytical chemistry, TBAI acts as a valuable reagent in chromatographic techniques, aiding in the effective separation and precise analysis of complex mixtures. The biotechnology sector also benefits from TBAI, particularly in the extraction and purification of biomolecules, where it helps enhance both the yield and purity of desired products.

From a pharmaceutical perspective, Tetra-n-butylammonium iodide is explored for its potential in drug formulation, specifically in improving the solubility and bioavailability of active pharmaceutical ingredients. Its ability to interact with and stabilize various organic molecules makes it a compelling candidate for enhancing drug delivery systems. For optimal storage, TBAI should be kept in a cool, dry, and well-ventilated area, preferably at temperatures not exceeding 30°C, to maintain its purity and efficacy over time.

As a leading manufacturer and supplier of high-quality chemical compounds, NINGBO INNO PHARMCHEM CO.,LTD. offers Tetra-n-butylammonium Iodide (CAS 311-28-4) with guaranteed purity, meeting the stringent requirements of various industries. For those looking to buy or purchase this essential chemical, our competitive price ensures excellent value. We are committed to providing reliable products for your research, development, and manufacturing needs.