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Methyl 2-fluoro-2-methylpropanoate: A Core Fluorinated Building Block

Methyl 2-fluoro-2-methylpropanoate, identified by its CAS Number 338-76-1, stands as a pivotal fluorinated compound in modern chemistry. Also known by synonyms such as methyl 2-fluoro-isobutyrate and 2-fluoro-2-methyl-propanoic acid, methyl ester, this chemical intermediate is highly valued for its unique properties conferred by the strategic placement of fluorine atoms. It serves as an essential building block across a multitude of industries, facilitating the synthesis of advanced materials, novel pharmaceuticals, and effective agrochemicals. The integration of fluorine often leads to enhanced biological activity, improved stability, and distinct physicochemical characteristics in target molecules, making Methyl 2-fluoro-2-methylpropanoate indispensable in various research and industrial applications.


This colorless to almost colorless clear liquid boasts a molecular formula of C5H9FO2 and a molecular weight of 120.12. Its typical density is around 1.03 g/cm3 at 20°C, and it exhibits a refractive index (n20D) generally in the range of 1.37 to 1.38. Methyl 2-fluoro-2-methylpropanoate has a boiling point ranging from 108-109°C, indicating its volatility and suitability for various reaction conditions. The presence of the fluoroalkyl group significantly influences its reactivity, making it a highly sought-after component for introducing fluorine into complex organic structures. Its robust chemical profile ensures stability and reliability in demanding synthetic pathways.


Methyl 2-fluoro-2-methylpropanoate's versatility is evident in its wide array of applications:

Pharmaceutical Development: This compound is a critical intermediate in the synthesis of numerous pharmaceuticals. Its ability to introduce fluorine into drug candidates can significantly enhance their efficacy, metabolic stability, and bioavailability, while potentially reducing side effects. It is vital for creating innovative fluorinated drugs across various therapeutic areas.

Agricultural Chemicals: In the agrochemical sector, Methyl 2-fluoro-2-methylpropanoate is employed in the formulation of advanced herbicides and pesticides. Fluorination can improve the selectivity and effectiveness of these agents against target pests and weeds, leading to more efficient and environmentally conscious agricultural practices.

Fluorinated Polymers and Materials: The chemical plays a key role in the production of fluorinated polymers and specialty materials. These materials are highly valued for their exceptional chemical resistance, thermal stability, and low surface energy, making them ideal for high-performance coatings, insulation, and protective applications in demanding environments.

Flavor and Fragrance Industry: Surprisingly, Methyl 2-fluoro-2-methylpropanoate also finds application in the flavor and fragrance industry. It contributes to the synthesis of specific flavoring agents and fragrances, allowing for the creation of unique and desired sensory profiles in food and cosmetic products.

Analytical Chemistry: Furthermore, it serves as a reliable standard in various analytical methods, aiding researchers in calibrating instruments and ensuring accurate measurements in complex chemical analyses.


As a versatile chemical compound, Methyl 2-fluoro-2-methylpropanoate continues to be indispensable for advancing innovative solutions across multiple sectors. Its ease of handling and compatibility with diverse reaction conditions allow for highly efficient synthesis processes, making it a preferred choice for chemists and researchers worldwide. We are committed to establishing a complete platform for fluorochemical products and technology, offering convenient one-stop services for a wide range of fluorine-containing material raw materials, fluorinated reagents, and building blocks. Our dedication to quality control ensures that Methyl 2-fluoro-2-methylpropanoate consistently meets the highest purity standards, typically exceeding 95% (GC), making it suitable for even the most demanding research and industrial needs. For those looking to buy high-quality Methyl 2-fluoro-2-methylpropanoate, we pride ourselves on being a reliable supplier and experienced manufacturer of fluorinated chemicals. We offer competitive price options and support bulk purchase inquiries, ensuring a steady and secure supply chain for your advanced chemical synthesis projects.

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