N-Iodosuccinimide, commonly abbreviated as NIS, with CAS number 516-12-1, stands as a pivotal chemical compound in modern organic synthesis and the pharmaceutical industry. This indispensable reagent is recognized for its unique properties and extensive applications, making it a cornerstone in various chemical transformations. NINGBO INNO PHARMCHEM CO.,LTD. is proud to offer high-quality N-Iodosuccinimide, manufactured to rigorous standards to meet the diverse needs of researchers and industrial clients worldwide.

Chemically, N-Iodosuccinimide possesses the molecular formula C4H4INO2 and a molecular weight of approximately 224.98 g/mol. It typically appears as an off-white to light yellow crystalline powder, although it can also be found as white-yellow to brown crystalline powder or even colorless needles. Its melting point generally ranges between 192°C and 206°C, often with decomposition. NIS exhibits a density of 2.245 g/cm3 and is notable for its solubility in polar organic solvents such as dioxane, tetrahydrofuran, and acetonitrile, while remaining insoluble in ether and carbon tetrachloride. It is important to note that NIS is sensitive to both moisture and light, necessitating careful handling and storage.

The synthesis of N-Iodosuccinimide can be achieved through several established routes. One common method involves the reaction of succinimide with freshly precipitated silver oxide, followed by the reaction of the resulting silver salt of succinimide with iodine in a controlled temperature environment, typically between 5-10°C. Another effective approach entails stirring succinimide with iodine and [bis(acetoxy)iodo]benzene in an inert solvent like benzene. NINGBO INNO PHARMCHEM CO.,LTD. employs advanced manufacturing processes to ensure a high purity product, consistently achieving an assay of 99% or higher, critical for demanding synthetic applications.

The utility of N-Iodosuccinimide spans a wide spectrum of chemical reactions. It is widely employed as a mild and selective iodinating agent for various organic substrates. Its primary applications include the iodination of ketones and aldehydes in complex organic syntheses, facilitating the introduction of iodine atoms into specific positions. NIS is also instrumental in the selective chemolysis of thioglycosides with trifluoroacetic acid to yield 1-hydroxyglycosides, a key transformation in carbohydrate chemistry.

Furthermore, N-Iodosuccinimide acts as a source of I+ in Hunsdiecker reactions, enabling the conversion of cinnamic acids and propiolic acids into their corresponding alpha-halostyrenes and 1-halo-1-alkynes, respectively. It is also a valuable reagent for the preparation of vinyl sulfones from olefins and benzenesulfinic acid, and plays a role in the synthesis of iodobenzene from 1,6-diynes. Beyond these, NIS serves as a sulfur oxidation titration reagent and a glucosinolate catalyst. In the biopharmaceutical sector, N-Iodosuccinimide is frequently utilized as a crucial pharmaceutical intermediate, underscoring its importance in drug discovery and development.

For optimal product integrity and safety, N-Iodosuccinimide should be stored in a cool, dry, and well-ventilated area, with containers kept tightly closed. Due to its sensitivity to moisture and light, protecting it from these elements is paramount. As a leading manufacturer and supplier of N-Iodosuccinimide, NINGBO INNO PHARMCHEM CO.,LTD. ensures reliable supply and competitive pricing. To learn more about how to buy or purchase N-Iodosuccinimide, or for specific price inquiries, please reach out to our dedicated sales team.