Phenylacetyl Chloride (CAS 103-80-0) stands as a pivotal organic compound with a molecular formula of C8H7ClO and a molecular weight of approximately 154.59 g/mol. This colorless to light yellow transparent liquid is characterized by its distinct, irritating odor. As a highly reactive acyl chloride, it plays a fundamental role in various chemical transformations due to the presence of its acyl group. Its physical properties include a density of around 1.165 g/mL (at 20ºC), a melting point of -19ºC, and a boiling point typically ranging from 219 to 225ºC. Phenylacetyl Chloride is known to be slightly soluble in water, reacting upon contact, but demonstrates excellent solubility in common organic solvents such as ether, benzene, and chloroform, making it highly versatile for diverse synthetic applications.

The versatility of Phenylacetyl Chloride extends across multiple industries, making it an indispensable chemical intermediate. In the pharmaceutical industry, it serves as a crucial building block for the synthesis of numerous active pharmaceutical ingredients. Notably, it is widely utilized in the production of penicillin-like antibiotics, a class of life-saving drugs essential for combating bacterial infections. Furthermore, its derivatives are integral to the development of certain central nervous system drugs. Beyond pharmaceuticals, Phenylacetyl Chloride finds significant application in the flavor and fragrance industry. It is employed in the synthesis of specific flavor and fragrance compounds, contributing unique aromatic profiles to a variety of consumer products. In broader chemical synthesis, this compound is highly valued for its ability to introduce the phenylacetyl group into various organic molecules. This reaction facilitates the construction of complex organic molecular structures, such as forming amides when reacted with amines or esters when reacted with alcohols. It is also an important reagent in the manufacturing of dyes and in the preparation of specialized chemical compounds like 1,2-diphenyl-ethanone.

Given its chemical nature, Phenylacetyl Chloride demands careful handling and adherence to stringent safety protocols. It is classified as a toxic and corrosive substance, capable of causing severe irritation and damage to the skin, eyes, and respiratory tract. Direct contact or inhalation of its vapors can lead to burns and adverse health effects on mucous membranes. A critical safety consideration is its reactivity with water, which results in the release of highly corrosive and irritating hydrogen chloride gas. Therefore, contact with moisture must be strictly avoided. For safe storage, Phenylacetyl Chloride should be kept in a cool, dry, and well-ventilated area, securely sealed away from sources of ignition, heat, and incompatible materials. Incompatible substances include amines, most common metals, strong bases, and strong oxidizing agents, which can lead to hazardous reactions. When handling this chemical, appropriate personal protective equipment (PPE) is mandatory, including chemical-resistant gloves, safety goggles or a face shield, and a respirator. In the event of a spill or leak, immediate containment and cleanup measures are essential to prevent environmental contamination and mitigate safety hazards, ensuring the well-being of personnel and the surrounding environment.

Ensuring the highest purity, typically 98% to 99% or above, is paramount for the effective and safe application of Phenylacetyl Chloride in sensitive industries like pharmaceuticals. Reputable manufacturer and supplier companies prioritize rigorous quality control to meet industry standards. For those looking to buy or purchase Phenylacetyl Chloride, it is advisable to source from an established supplier with proven capabilities in chemical synthesis and robust logistics. The price of Phenylacetyl Chloride can vary depending on purity, quantity, and market dynamics, with bulk purchase options often providing more cost-effective solutions. Packaging solutions are flexible, typically including drums of various sizes (e.g., 25 kg, 200 kg) or IBC drums (1000 kg), and even bulk tank containers for large-scale requirements, ensuring convenient delivery for different client needs. When considering where to buy Phenylacetyl Chloride, prospective clients should evaluate a supplier's ability to offer customized packaging, fast delivery, and comprehensive technical support. Choosing a reliable manufacturer and supplier is crucial for consistent quality and supply chain stability, whether for small laboratory quantities or large industrial orders.