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Peptide synthesis is a critical area of organic chemistry and biochemistry, underpinning advancements in pharmaceuticals, diagnostics, and biomaterials. The ability to synthesize modified peptides with tailored properties is essential for unlocking new therapeutic and research applications. NINGBO INNO PHARMCHEM CO.,LTD. provides Azido-PEG3-Alcohol (N3-PEG3-OH), a reagent that significantly aids in polypeptide synthesis by acting as a versatile linker.
Peptides, composed of amino acid sequences, often require modifications to improve their stability, solubility, or targeting capabilities. The incorporation of polyethylene glycol (PEG) chains, a process known as PEGylation, is a common strategy to achieve these enhancements. Azido-PEG3-Alcohol offers a unique way to introduce PEGylation into peptides, thanks to its bifunctional nature.
The azide group on N3-PEG3-OH is a key component for conjugation. It readily participates in 'click chemistry' reactions, particularly the copper-catalyzed azide-alkyne cycloaddition (CuAAC) and strain-promoted azide-alkyne cycloaddition (SPAAC). This allows for the efficient and specific attachment of the PEG moiety to peptides that have been synthesized with an alkyne or other compatible group. The high efficiency and mild reaction conditions associated with click chemistry are crucial for preserving the integrity and biological activity of the synthesized peptides.
NINGBO INNO PHARMCHEM CO.,LTD. supplies Azido-PEG3-Alcohol with assured high purity, which is vital for reliable peptide synthesis. The triethylene glycol spacer provides a flexible, hydrophilic linkage that can improve the solubility of hydrophobic peptides and increase their resistance to enzymatic degradation. This leads to peptides with longer half-lives in biological systems, a desirable trait for therapeutic peptides.
Furthermore, the hydroxyl terminus of Azido-PEG3-Alcohol offers flexibility in the synthetic design. It can be used to attach the PEG linker to specific amino acid residues within a peptide sequence, or it can be further derivatized before conjugation. This allows for precise control over the location and density of PEGylation, which can significantly impact the resulting peptide's properties.
Researchers in polypeptide synthesis leverage Azido-PEG3-Alcohol from NINGBO INNO PHARMCHEM CO.,LTD. to create a wide array of advanced peptide constructs. These include therapeutic peptides with improved pharmacokinetics, peptide-based drug delivery systems, and diagnostic peptides for imaging applications. The ability to reliably introduce PEG chains using click chemistry is a major advantage in streamlining the synthesis and purification processes.
By providing high-quality Azido-PEG3-Alcohol, NINGBO INNO PHARMCHEM CO.,LTD. supports the ongoing innovation in peptide synthesis, enabling scientists to explore new therapeutic avenues and develop next-generation peptide-based products.
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1. 20 years of R&D, manufacturing and sales experience, serving customers in 60 countries and regions around the world;
2. Own R&D laboratory, pilot platform and large-scale production workshop, which can meet the audit requirements of global customers;
3. We can satisfy customers' perfect transition from small scale lab requirements (gram level) to commercialization requirements (hundred tons level).
A: We don't have Minimum Order Quantity, exact quantity should be provided before quotation for us to calculate the exact cost.
A: We don't provide free samples due to lots of request and expensive international courier's cost, we can deduct the sample charge after commercial order placed.
A: Our payment terms: Small or sample order: T/T IN ADVANCE. Commercial order: First order should be by T/T IN ADVANCE or L/C at sight, and following orders T/T 30~90days is acceptable subject to approval of credit application.
