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Bioconjugation, the process of chemically linking two molecules of biological origin, is fundamental to numerous scientific disciplines, including molecular biology, diagnostics, and therapeutics. The ability to create stable and specific conjugates is essential for developing advanced tools and treatments. NINGBO INNO PHARMCHEM CO.,LTD. provides a vital reagent for this field: Azido-PEG3-Alcohol (N3-PEG3-OH).
Azido-PEG3-Alcohol is a bifunctional linker designed to bridge biomolecules with precision. It features a terminal azide group, which is highly reactive in 'click chemistry' reactions, and a hydroxyl group that offers a secondary point for attachment or modification. The triethylene glycol (PEG3) chain between these functional groups provides a flexible and hydrophilic spacer.
The primary utility of Azido-PEG3-Alcohol in bioconjugation lies in its azide group's participation in click reactions, such as the copper-catalyzed azide-alkyne cycloaddition (CuAAC) or strain-promoted azide-alkyne cycloaddition (SPAAC). These reactions are renowned for their high efficiency, specificity, and ability to proceed under mild, physiological conditions, making them ideal for modifying sensitive biological molecules like proteins, antibodies, and nucleic acids without causing denaturation.
NINGBO INNO PHARMCHEM CO.,LTD. ensures the high purity of Azido-PEG3-Alcohol, which is critical for successful bioconjugation. Impurities can lead to non-specific reactions or reduced conjugation efficiency, compromising the integrity of the final conjugate. Researchers can rely on the consistent quality of this reagent for reproducible experimental outcomes.
The hydroxyl group on Azido-PEG3-Alcohol adds another layer of versatility. It can be activated to react with carboxyl groups on biomolecules, forming stable ester linkages. Alternatively, it can be converted into other functional groups, such as activated esters or maleimides, allowing for conjugation with different types of biomolecules. This flexibility enables the creation of complex bioconjugates for diverse applications.
For example, in developing antibody-drug conjugates (ADCs), Azido-PEG3-Alcohol can serve as a linker between an antibody and a cytotoxic drug. The PEG chain can improve the drug's solubility and circulation time, while the azide and hydroxyl groups allow for precise attachment to both the antibody and the drug payload. Similarly, it can be used to label proteins with fluorescent dyes or to immobilize biomolecules onto surfaces for diagnostic assays.
By providing high-quality Azido-PEG3-Alcohol, NINGBO INNO PHARMCHEM CO.,LTD. empowers scientists to perform precise and efficient bioconjugations. This capability is fundamental to advancing research in molecular diagnostics, targeted therapeutics, and the development of novel biomaterials.
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1. 20 years of R&D, manufacturing and sales experience, serving customers in 60 countries and regions around the world;
2. Own R&D laboratory, pilot platform and large-scale production workshop, which can meet the audit requirements of global customers;
3. We can satisfy customers' perfect transition from small scale lab requirements (gram level) to commercialization requirements (hundred tons level).
A: We don't have Minimum Order Quantity, exact quantity should be provided before quotation for us to calculate the exact cost.
A: We don't provide free samples due to lots of request and expensive international courier's cost, we can deduct the sample charge after commercial order placed.
A: Our payment terms: Small or sample order: T/T IN ADVANCE. Commercial order: First order should be by T/T IN ADVANCE or L/C at sight, and following orders T/T 30~90days is acceptable subject to approval of credit application.
