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The development of effective drug formulations often hinges on overcoming the inherent challenges posed by poorly soluble active pharmaceutical ingredients (APIs). Povidone K90 (PVP K90), a high molecular weight, water-soluble polymer, has proven to be a critical tool in addressing these formulation hurdles, particularly in enhancing drug solubility and bioavailability.
PVP K90 functions effectively as a solubilizer and a component in solid dispersion formulations. By forming molecular complexes with poorly soluble drugs, it can increase their apparent solubility and dissolution rate. This is achieved through various mechanisms, including the creation of amorphous solid dispersions where the drug is molecularly dispersed within the polymer matrix, preventing recrystallization and promoting faster dissolution upon administration.
The hydrophilic nature of Povidone K90 allows it to readily interact with water, facilitating the dispersion and dissolution of hydrophobic APIs. This property is particularly valuable in oral solid dosage forms like tablets and capsules, where rapid drug release and absorption are paramount for achieving therapeutic efficacy. When used as a binder in tablet manufacturing, Povidone K90 not only provides mechanical strength but also contributes to the overall drug release profile.
The impact of PVP K90 on bioavailability is significant. By improving the dissolution rate, it ensures that a greater amount of the active drug is available for absorption into the bloodstream, leading to more predictable and potent therapeutic effects. This is especially crucial for drugs with narrow therapeutic windows or those that are poorly absorbed in their native state.
Manufacturers like NINGBO INNO PHARMCHEM CO.,LTD. provide high-quality Povidone K90 that adheres to stringent pharmaceutical standards. This ensures that formulators can confidently incorporate PVP K90 into their products, knowing they are utilizing a reliable excipient that enhances drug performance. The scientific community continues to explore and validate the role of Povidone K90 in advanced drug delivery systems, underscoring its ongoing importance in pharmaceutical innovation.
In summary, Povidone K90 is more than just a simple excipient; it is a functional ingredient that actively contributes to the therapeutic success of many medications by overcoming critical formulation challenges related to solubility and bioavailability.
Manufacturing Facilities
Professional Export Experience
to Global Customers
1. 20 years of R&D, manufacturing and sales experience, serving customers in 60 countries and regions around the world;
2. Own R&D laboratory, pilot platform and large-scale production workshop, which can meet the audit requirements of global customers;
3. We can satisfy customers' perfect transition from small scale lab requirements (gram level) to commercialization requirements (hundred tons level).
A: We don't have Minimum Order Quantity, exact quantity should be provided before quotation for us to calculate the exact cost.
A: We don't provide free samples due to lots of request and expensive international courier's cost, we can deduct the sample charge after commercial order placed.
A: Our payment terms: Small or sample order: T/T IN ADVANCE. Commercial order: First order should be by T/T IN ADVANCE or L/C at sight, and following orders T/T 30~90days is acceptable subject to approval of credit application.
