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(S)-(+)-3-Chloro-1,2-propanediol: A Key Chiral Intermediate for Pharma

(S)-(+)-3-Chloro-1,2-propanediol, identified by its CAS number 60827-45-4, stands as a pivotal chiral building block in the realm of advanced chemical synthesis. This specialized compound is indispensable for a wide array of applications, particularly within the pharmaceutical sector, where precise molecular structures and high enantiomeric purity are paramount. Its unique chemical characteristics make it a cornerstone for developing complex organic molecules and various intermediates.


Chemically, (S)-(+)-3-Chloro-1,2-propanediol possesses the molecular formula C3H7ClO2 and a molecular weight of 110.53900 g/mol. It typically appears as a clear yellow to orange-yellow liquid. Key physical properties include a boiling point of approximately 213 °C and a density of 1.322 g/mL at 25 °C, with a refractive index of n20/D 1.480. This compound exhibits good stability under normal temperature and pressure conditions, a critical factor for its handling and storage in industrial environments. Its solubility profile further enhances its versatility in synthesis, being soluble in water, ethanol, acetone, methanol, and ether, while showing slight solubility in toluene. Maintaining a high purity, typically at 95% minimum, is crucial for its intended use in sensitive chemical processes, ensuring optimal reaction yields and product quality.


The primary application of (S)-(+)-3-Chloro-1,2-propanediol lies in its role as a key intermediate for the synthesis of chiral reagents and diverse pharmaceutical compounds. Chiral purity is often essential for drug efficacy and safety, making this specific enantiomer highly valuable. One significant derivative it contributes to is (R)-epichlorohydrin, a versatile precursor in the production of various resins and other fine chemicals. Beyond pharmaceuticals, its utility extends to other high-value chemical syntheses where specific stereochemistry is required, underpinning advancements in material science and specialized chemical development.


For industries relying on such critical intermediates, the selection of a reliable manufacturer and supplier is non-negotiable. Ensuring a consistent supply of high-quality (S)-(+)-3-Chloro-1,2-propanediol is vital for uninterrupted production and development cycles. A reputable provider focuses on stringent quality control measures, from raw material sourcing to final product packaging, guaranteeing that each batch meets exacting specifications. This commitment to excellence translates into enhanced reliability for downstream applications and ultimately, safer and more effective end-products.


When considering where to buy or purchase this essential chemical, factors such as purity, lot-to-lot consistency, competitive price, and efficient logistics are paramount. Leading suppliers are equipped with the technical expertise and infrastructure to support diverse client needs, offering bulk quantities readily available in stock. The availability of free samples, as a testament to product quality, can further assist researchers and manufacturers in their preliminary evaluations, allowing for confident integration into their processes. Partnering with an experienced supplier ensures access to comprehensive product information and support, facilitating seamless procurement and application of this indispensable chiral intermediate.

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