Sulfachloropyrazine Sodium, also widely recognized by its CAS number 102-65-8, stands as a critical active pharmaceutical ingredient (API) in the veterinary industry. Often referred to as Sulfaclozine Sodium, this potent sulfonamide antibiotic is a cornerstone in maintaining the health and productivity of livestock, particularly poultry. Its efficacy against a range of debilitating diseases makes it an indispensable tool for veterinarians and animal farmers worldwide.

This valuable compound typically presents as a slight-yellow or yellowish powder, signifying its high purity, often exceeding 98% or even 99% by HPLC. Its physical characteristics, including its solid state and specific solubility profile – being soluble in water and methanol, slightly in ethanol and acetone, yet insoluble in chloroform – are vital for its various formulations and applications in animal medicine.

The therapeutic power of Sulfachloropyrazine Sodium stems from its intricate mechanism of action. As a sulfonamide drug, it acts as a competitive antagonist of para-aminobenzoic acid (PABA). PABA is a crucial precursor for the synthesis of dihydrofolic acid, which is then converted into folic acid. Folic acid, in turn, is a coenzyme essential for the synthesis of nucleic acids in many protozoa and bacteria. By competing with PABA for dihydrofolic acid synthetase, Sulfachloropyrazine Sodium effectively inhibits the synthesis of dihydrofolate and nucleoprotein. This disruption prevents sensitive microbial species, including various Eimeria species (responsible for coccidiosis), Salmonella gallinarum (causing fowl typhoid), and Pasteurella multocida (leading to fowl cholera), from multiplying. Its anticoccidial effect is particularly notable on the second generation of coccidium schizonts, with some impact on the first generation as well.

Upon oral administration, Sulfachloropyrazine Sodium exhibits favorable pharmacokinetic properties. It is rapidly absorbed in the alimentary canal, reaching peak blood concentration within 3-4 hours. Following its therapeutic action, the drug is quickly excreted through urine, minimizing residual concerns. This swift absorption and elimination profile contribute to its effectiveness and safety in veterinary applications.

The primary application of Sulfachloropyrazine Sodium is the treatment and control of coccidiosis in poultry, a parasitic disease that causes significant economic losses in the poultry industry. Beyond coccidiosis, it is also indicated for treating fowl typhoid and fowl cholera. While predominantly used in chickens, its utility extends to other animals like lambs, calves, and rabbits for coccidiosis treatment, and it is also valuable in coccidiosis research studies. Typical usage involves water premixes (e.g., 1g per liter of water) or feed premixes (e.g., 2000g per 1000kg of feed), often administered for three consecutive days, with potential for repeat cycles after a short break, depending on the severity and type of infection.

NINGBO INNO PHARMCHEM CO.,LTD. is a dedicated manufacturer and supplier of high-quality Sulfachloropyrazine Sodium (CAS 102-65-8). We adhere to stringent quality control standards to ensure that every batch of this essential veterinary API meets rigorous specifications for purity and efficacy. We understand the critical importance of reliable and effective pharmaceutical ingredients for animal health, and our commitment to quality is unwavering. For those looking to buy Sulfachloropyrazine Sodium or inquire about its price, we encourage direct communication to discuss your specific needs. Our comprehensive manufacturing process ensures a stable and consistent supply, making us a dependable partner for your purchase requirements of veterinary APIs. Contact us to learn more about our product offerings and how we can support your animal health initiatives.