Amino-PEG12-t-butyl Ester: A Versatile Bifunctional Linker for Bioconjugation and Drug Delivery
Explore the cutting-edge applications of Amino-PEG12-t-butyl ester, a key component in modern bioconjugation and advanced pharmaceutical development. Discover its role in enhancing solubility, stability, and targeted delivery.
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Amino-PEG12-t-butyl ester
We are a reliable supplier in China for high-quality chemical intermediates like Amino-PEG12-t-butyl ester. This compound is a crucial bifunctional PEG linker, designed for advanced applications in bioconjugation and drug delivery systems. Its unique structure, featuring a reactive amine group and a tert-butyl protected carboxyl terminus connected by a 12-unit PEG chain, offers exceptional versatility for complex chemical modifications and formulations.
- Amino-PEG12-t-butyl ester serves as a vital chemical intermediate for bioconjugation, enabling the precise attachment of molecules for research and therapeutic purposes.
- Leveraging PEGylation in drug delivery, this linker enhances the pharmacokinetic profiles of various therapeutic agents.
- It is a key component in the development of antibody-drug conjugate linkers, facilitating the creation of targeted cancer therapies.
- As a versatile compound for chemical synthesis applications, it offers a reliable route for creating complex molecular structures.
Advantages Provided by the Product
Enhanced Biocompatibility
The polyethylene glycol (PEG) chain in Amino-PEG12-t-butyl ester significantly improves the biocompatibility and aqueous solubility of conjugated molecules, crucial for drug delivery systems.
Versatile Reactivity
With a primary amine and a protected carboxyl group, this compound offers dual functionality, allowing for sequential conjugation strategies and expanded possibilities in bioconjugation.
Controlled Deprotection
The tert-butyl protected carboxyl group can be selectively deprotected under mild acidic conditions, revealing a reactive carboxylic acid for subsequent modifications, essential for complex chemical synthesis applications.
Key Applications
Bioconjugation
Amino-PEG12-t-butyl ester is instrumental in bioconjugation, enabling the precise linking of proteins, peptides, and other biomolecules for research and therapeutic purposes, utilizing its amine functionality.
Drug Delivery Systems
It plays a critical role in enhancing the efficacy and delivery of therapeutic agents by improving their solubility, stability, and circulation time, a key aspect of modern drug delivery systems.
Antibody-Drug Conjugates (ADCs)
As a component in antibody-drug conjugate linkers, it facilitates the development of targeted cancer therapies by connecting antibodies to cytotoxic payloads.
Diagnostic Imaging
The compound can be integrated into imaging agents, allowing for improved visualization and diagnostics in medical research and clinical applications.