HATU: The Advanced Peptide Coupling Reagent for Efficient Amide Bond Formation
Unlock superior peptide synthesis with HATU, the golden standard for amide bond formation and difficult coupling challenges.
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HATU Hexafluorophosphate Azabenzotriazole Tetramethyl Uronium
HATU is a superior coupling reagent in peptide chemistry, renowned for its high efficiency in forming amide bonds, particularly in challenging syntheses. It significantly reduces epimerization, a critical factor for peptide integrity. This reagent is a cornerstone for both solid-phase peptide synthesis (SPPS) and solution-phase applications, including the development of peptide-drug conjugates.
- Experience enhanced coupling efficiency for peptide synthesis, a key benefit of using HATU in your organic synthesis workflow.
- Minimize epimerization during peptide coupling, ensuring the structural fidelity of your synthesized peptides, crucial for pharmaceutical intermediates.
- Utilize a reliable reagent for difficult couplings, a common challenge in advanced peptide chemistry and drug discovery efforts.
- Leverage HATU's stability and solubility in polar aprotic solvents, making it a versatile choice for various peptide chemistry applications.
Advantages Offered by the Product
Exceptional Coupling Efficiency
HATU offers unparalleled efficiency in forming amide bonds, ensuring high yields and rapid reaction times for your peptide synthesis needs.
Minimized Epimerization
A key advantage of HATU is its ability to suppress epimerization, preserving the chiral integrity of amino acids during coupling, which is vital for producing high-quality pharmaceutical intermediates.
Versatility in Applications
From standard solid-phase peptide synthesis to complex fragment condensations and peptide-drug conjugate construction, HATU is a trusted reagent for diverse peptide chemistry challenges.
Key Applications
Peptide Synthesis
HATU is a golden standard reagent for solid-phase peptide synthesis (SPPS) and solution-phase synthesis, enabling efficient formation of peptide bonds.
Amide Bond Formation
It is extensively used in organic synthesis for the efficient creation of amide linkages, a fundamental reaction in the creation of complex organic molecules.
Peptide-Drug Conjugates
HATU plays a crucial role in the development of peptide-drug conjugates (PDCs), facilitating the stable linkage of therapeutic agents to peptide carriers.
Difficult Couplings
When facing sterically hindered or less reactive amino acids, HATU often proves effective where other coupling reagents fail, ensuring successful synthesis outcomes.