High-Quality 2-Chlorotrityl Chloride Resin for Efficient Solid-Phase Peptide Synthesis | Supplier
Discover the advantages of 2-Chlorotrityl Chloride Resin, a critical component for advanced solid-phase peptide synthesis and organic chemistry. Experience unparalleled efficiency and mild cleavage for your complex molecular constructions.
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2-Chlorotrityl Chloride Resin
As a leading supplier in China, we offer high-purity 2-Chlorotrityl Chloride Resin, essential for advanced peptide synthesis. This resin is renowned for its acid-labile nature, enabling mild cleavage of protected peptide fragments, thereby preserving sensitive functional groups. Its unique structure minimizes side reactions like diketopiperazine formation, crucial for achieving high yields and purity in complex peptide sequences.
- Minimize diketopiperazine formation during peptide synthesis: Leverage our resin's design to ensure superior peptide chain integrity.
- Achieve mild cleavage for sensitive molecules: Utilize the resin's acid-labile properties for gentle release of synthesized compounds, a key aspect of preparing protected peptide fragments.
- Benefit from its versatility in organic synthesis: Beyond peptide chemistry, this solid support is effective for various organic synthesis applications, serving as a reliable intermediate.
- Ensure high loading capacity for efficient synthesis: Maximize your synthetic output with a resin designed for optimal functionalization and efficient coupling reactions.
Advantages Offered
Mild Acid Cleavage
The key advantage of our 2-Chlorotrityl Chloride Resin lies in its ability to cleave synthesized compounds under extremely mild acidic conditions. This is vital for maintaining the integrity of acid-sensitive protecting groups and complex molecular structures, a critical factor when preparing protected peptide fragments.
Reduced Side Reactions
The steric bulk of this resin effectively inhibits diketopiperazine (DKP) formation, a common side reaction in peptide synthesis, especially with C-terminal proline. This characteristic contributes significantly to cleaner reactions and higher yields, supporting efficient solid-phase peptide synthesis.
Broad Applicability
While exceptionally useful for Solid-Phase Peptide Synthesis (SPPS), the 2-Chlorotrityl Chloride Resin is also a versatile tool for oligonucleotide synthesis and the preparation of various small organic molecules, showcasing its broad utility in chemical research and development.
Key Applications
Solid-Phase Peptide Synthesis (SPPS)
Used for the preparation of protected peptide fragments via the Fmoc/tBu strategy, benefiting from mild cleavage and reduced side reactions in solid-phase peptide synthesis.
Organic Synthesis
Serves as a valuable solid support and protecting group reagent for carboxylic acids, facilitating the synthesis of diverse small organic molecules.
Drug Discovery
Enables the synthesis of small-molecule libraries, making it a critical component in early-stage drug discovery and development processes.
Chemical Research
A versatile reagent for academic and industrial research, supporting various synthetic methodologies requiring acid-labile solid supports.