MRT67307: A Potent TBK1/IKKε Inhibitor for Inflammatory and Autophagy Research
Explore the dual inhibitory capabilities of MRT67307, a key molecule in modulating immune responses and cellular processes like autophagy, with significant implications in treating inflammatory conditions and viral infections.
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MRT67307
As a reliable supplier of research chemicals, we offer MRT67307, a highly effective dual inhibitor of TBK1 and IKKε. This compound is instrumental in understanding and developing treatments for a range of inflammatory diseases and viral infections by targeting key signaling pathways.
- MRT67307 is a dual inhibitor of the TBK1/IKKε signaling pathway, crucial for modulating IRF3 phosphorylation and inflammatory responses.
- The compound also exhibits inhibitory activity against Salt Inducible Kinases (SIKs), MARK kinases, and NUAK1, and is a potent inhibitor of ULK1 and ULK2, impacting autophagy.
- MRT67307 has demonstrated significant efficacy in preclinical models, notably in reducing lung immunopathology associated with SARS-CoV-2 infection.
- It plays a role in regulating cytokine production, increasing anti-inflammatory IL-10 and decreasing pro-inflammatory cytokines like IL-6 and TNF.
Advantages Provided by the Product
Targeted Inhibition
MRT67307 offers precise inhibition of TBK1 and IKKε, allowing researchers to dissect their roles in innate immunity and inflammatory signaling, contributing to novel therapeutic strategies.
Modulation of Autophagy
As an inhibitor of ULK1 and ULK2, MRT67307 provides a tool for studying the intricate mechanisms of autophagy, a process vital for cellular homeostasis and implicated in various diseases.
Therapeutic Potential
Pre-clinical studies highlight MRT67307's potential in mitigating severe immunopathology, particularly in respiratory viral infections, positioning it as a candidate for drug development.
Key Applications
Inflammation Research
Investigate the role of TBK1/IKKε in inflammatory pathways and develop new treatments for autoimmune and inflammatory conditions by utilizing MRT67307.
Antiviral Drug Development
Explore the potential of MRT67307 to manage hyper-inflammation in viral infections like SARS-CoV-2, contributing to the development of effective antiviral therapies.
Autophagy Pathway Studies
Utilize MRT67307 to research the complex mechanisms of autophagy and its involvement in cellular health and disease.
Immune Signaling Pathways
Elucidate the functions of IRF3 phosphorylation and cytokine regulation by employing MRT67307 as a specific inhibitor.