1-Hydroxy-7-azabenzotriazole

Product Overview

1-Hydroxy-7-azabenzotriazole, commonly known as HOAT, is a highly specialized chemical reagent extensively utilized in the field of peptide synthesis and organic chemistry. As a superior alternative to traditional coupling additives, this compound plays a critical role in enhancing reaction efficiency and minimizing unwanted side reactions. Our facility produces this material under strict quality control standards to ensure consistent performance for research and industrial applications.

This compound functions primarily as an additive in carbodiimide-mediated couplings. By forming active esters with carboxylic acids, it significantly accelerates the aminolysis step while effectively suppressing racemization of chiral centers. This makes it an indispensable tool for synthesizing complex peptide sequences where stereochemical integrity is paramount.

Key Advantages

• Enhanced Coupling Efficiency: Dramatically reduces reaction times compared to standard protocols.
• Racemization Suppression: Protects chiral integrity during sensitive peptide bond formation.
• High Purity Standards: Manufactured to exceed 99.0% purity via HPLC analysis.
• Versatile Application: Suitable for both solid-phase and solution-phase synthesis strategies.
• Stable Supply Chain: Reliable bulk production capacity with global logistics support.

Technical Specifications

Industrial Applications

HOAT is predominantly employed in the pharmaceutical and biotechnology sectors for the construction of peptide-based therapeutics. It is particularly valuable when coupling sterically hindered amino acids or when working with sequences prone to epimerization. Beyond peptide synthesis, it serves as a robust condensation reagent in the preparation of esters and amides for various fine chemical intermediates.

Our manufacturing process ensures that each batch meets rigorous analytical criteria. We utilize advanced chromatography techniques to verify purity levels and confirm the absence of critical impurities. Every shipment is accompanied by a comprehensive Certificate of Analysis (COA) to facilitate quality assurance within your laboratory or production line.

Storage and Handling

To maintain optimal stability, this product should be stored in a cool, ventilated environment away from direct sunlight and moisture. Proper sealing of containers is essential to prevent degradation. When handling, appropriate personal protective equipment (PPE) including gloves and safety goggles should be worn to ensure safety during weighing and transfer operations. For large-scale industrial use, consult our safety data sheets for detailed hazard information and handling guidelines.