2'-O-Methyl-5-Methyluridine

Product Overview

2'-O-Methyl-5-Methyluridine is a specialized modified nucleoside that plays a critical role in the field of medicinal chemistry and biochemical research. As a derivative of uridine, this compound features a methyl group at the 2'-O position and a methyl substitution at the 5-position of the pyrimidine base. These structural modifications significantly enhance the stability and binding affinity of oligonucleotides incorporating this building block. Our facility produces this compound under strict quality control measures to ensure it meets the rigorous demands of pharmaceutical research and development.

The introduction of the 2'-O-methyl group is particularly valuable because it confers resistance to nuclease degradation, thereby extending the half-life of therapeutic oligonucleotides in biological systems. This makes 2'-O-Methyl-5-Methyluridine an essential component for scientists developing antisense oligonucleotides, siRNA, and other gene-silencing technologies. We are committed to supplying this high-value chemical intermediate to global partners with consistent quality and reliable availability.

Technical Specifications

Our manufacturing process ensures that every batch of 2'-O-Methyl-5-Methyluridine adheres to stringent purity standards suitable for sensitive laboratory applications. The physical characteristics and chemical parameters are rigorously tested using high-performance liquid chromatography and other analytical methods.

Industrial Applications

This modified nucleoside is primarily utilized in the synthesis of platinum-derivatized homopyrimidine triplex-forming oligonucleotides, known as Pt-TFOs. These specialized molecules are useful in crosslinking to the transcribed strand in the human androgen receptor gene, offering potential pathways for targeted gene therapy research. Additionally, studies have indicated inhibitory activity against specific mycobacterial strains, including M. bovis and M. avium, highlighting its potential in antimicrobial research contexts.

• Essential building block for oligonucleotide synthesis.
• Used in gene targeting and antisense technology development.
• Supports research into androgen receptor gene modulation.
• Applicable in antimicrobial and mycobacterial inhibition studies.
• Enhances nuclease resistance in therapeutic RNA structures.

Quality Assurance and Storage

We understand that consistency is key in chemical synthesis. Therefore, each production lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing all test results. Our packaging options are flexible, typically supplying 25 kg per drum, but we can accommodate specific customer requirements for smaller or larger quantities. To maintain optimal stability, the product should be stored in a cool, ventilated place away from direct sunlight and moisture. Proper storage ensures that the chemical integrity remains intact throughout its shelf life, guaranteeing performance in your downstream applications.