6-Chloro-1-hydroxybenzotriazole

Product Overview

6-Chloro-1-hydroxybenzotriazole, commonly abbreviated as Cl-HOBt, is a highly specialized chemical reagent extensively utilized in the field of organic synthesis and peptide chemistry. As a derivative of hydroxybenzotriazole, this compound serves as a superior additive in coupling reactions, significantly enhancing reaction rates while suppressing unwanted racemization during amide bond formation. Our manufacturing process ensures exceptional consistency, making it an ideal choice for complex pharmaceutical intermediate production and advanced peptide building block assembly.

In the context of modern medicinal chemistry, the demand for high-fidelity coupling agents is critical. Cl-HOBt offers distinct advantages over standard HOBt due to the electron-withdrawing chlorine substituent, which modulates its reactivity profile. This results in improved solubility in common organic solvents and heightened efficiency in solid-phase peptide synthesis (SPPS) as well as solution-phase methodologies. We commit to delivering this essential reagent with strict adherence to international quality standards.

Technical Specifications

Industrial Applications

The primary application of 6-Chloro-1-hydroxybenzotriazole lies in its function as a potent polypeptide condensing agent. It is indispensable in the synthesis of bioactive peptides, protease inhibitors, and various pharmaceutical intermediates where stereochemical integrity must be preserved. By forming active esters with carboxylic acids, Cl-HOBt facilitates nucleophilic attack by amines, thereby driving the coupling reaction to completion with high yields.

Beyond peptide synthesis, this compound finds utility in the preparation of fine chemicals and specialized organic structures requiring mild yet effective activation conditions. Its stability and performance make it a preferred choice for process chemistry teams aiming to optimize manufacturing routes for active pharmaceutical ingredients (APIs). Whether used in research-scale development or large-scale production, our material supports rigorous experimental requirements.

Quality Assurance and Safety

Quality is the cornerstone of our supply chain. Every batch of 6-Chloro-1-hydroxybenzotriazole undergoes comprehensive analytical testing, including HPLC, NMR, and moisture analysis, to verify compliance with specified purity levels. We provide a Certificate of Analysis (COA) with every shipment, ensuring full traceability and transparency for our global partners.

Regarding safety, this product is classified under Hazard Class 4.1 (Flammable Solid). It should be stored in a cool, ventilated area away from ignition sources and incompatible materials. Proper personal protective equipment (PPE) is recommended during handling to prevent inhalation or skin contact. Our packaging options include 25 kg drums, with customization available to meet specific logistical needs. We prioritize safe transport protocols in accordance with UN regulations (UN1325) to ensure the product arrives in optimal condition.