D-Leucine
- CAS No.328-38-1
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High purity D-Leucine (CAS 328-38-1) designed for advanced peptide synthesis and chiral research applications with strict quality control.
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Product Overview
D-Leucine, chemically known as (R)-2-Amino-4-methylpentanoic acid, is a critical chiral building block utilized extensively in the pharmaceutical and fine chemical industries. As a non-proteinogenic amino acid enantiomer, it serves as an essential precursor in the synthesis of complex peptide structures and specialized organic compounds. Our manufacturing facility adheres to rigorous international standards to ensure that every batch of D-Leucine meets the highest specifications for optical purity and chemical integrity.
We understand that consistency is paramount in multi-step synthesis routes. Therefore, our production process is optimized to minimize the presence of the L-isomer, ensuring that downstream reactions proceed with maximum efficiency and yield. This product is ideal for research laboratories and industrial-scale manufacturing requiring reliable chiral intermediates.
Key Specifications
| Parameter | Specification |
|---|---|
| Solubility in 3M-HCl | Colorless and clear (c=5) |
| Specific Rotation [α]D20 | -14.8° to -15.7° (c=4, 6M-HCl) |
| Loss on Drying | Not more than 0.3% |
| Residue on Ignition | Not more than 0.1% |
| Assay (Purity) | 98.5% to 101.0% |
| L-Isomer Impurity | Not more than 0.5% |
| Heavy Metals (as Pb) | Not more than 10ppm |
| Other Amino Acids | Not detected by T.L.C. |
Quality Assurance and Control
Quality is the cornerstone of our chemical supply chain. Each batch of D-Leucine undergoes comprehensive analytical testing using high-performance liquid chromatography (HPLC) and thin-layer chromatography (TLC) to verify identity and purity. We strictly monitor critical impurities such as heavy metals, iron, arsenic, and ammonium to ensure compliance with safety regulations for industrial handling.
- Strict control of optical rotation to guarantee chiral integrity.
- Low moisture content ensures stability during storage and transport.
- Minimal inorganic residue guarantees high performance in sensitive reactions.
- Comprehensive documentation including Certificate of Analysis (COA) provided with every shipment.
Industrial Applications
Due to its high optical purity and low contamination profile, this grade of D-Leucine is primarily employed in the synthesis of peptide mimetics and pharmaceutical intermediates. It is also utilized in the development of chiral catalysts and as a standard reference material in analytical chemistry. Our global logistics network ensures timely delivery to support continuous manufacturing operations without interruption.
Storage and Handling
To maintain product stability, D-Leucine should be stored in a cool, dry, and well-ventilated area away from direct sunlight and moisture. Containers must be kept tightly sealed when not in use to prevent absorption of atmospheric humidity. Proper personal protective equipment (PPE) is recommended during handling to ensure safety in accordance with standard chemical hygiene practices.
