Peptides & Building Blocks

D-Proline

  • CAS No.344-25-2
  • GradeIndustrial / Pharmaceutical
  • Availability● In Stock

High purity D-Proline (CAS 344-25-2) serves as a critical chiral building block for pharmaceutical API synthesis and peptide manufacturing. Available in bulk with full COA.

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Product Technical Details

Product Overview

D-Proline, chemically recognized as (2R)-2-Pyrrolidinecarboxylic acid, stands as a pivotal chiral building block within the modern pharmaceutical and fine chemical industries. As the enantiomer of the naturally occurring L-Proline, this compound offers unique stereochemical properties that are essential for the synthesis of complex organic molecules and active pharmaceutical ingredients. Our facility specializes in the production of high-purity D-Proline, catering to the rigorous demands of API manufacturing and advanced peptide synthesis laboratories worldwide. The compound is characterized by its exceptional stability and specific reactivity, making it an indispensable tool for medicinal chemists aiming to introduce precise chirality into drug candidates. We ensure that every batch meets stringent quality benchmarks suitable for large-scale industrial applications.

Key Specifications

Quality consistency is the cornerstone of our manufacturing process. We adhere to strict internal standards that often exceed typical industry requirements for amino acid derivatives. Each batch undergoes comprehensive analytical testing using advanced chromatography and spectroscopy methods to ensure parameters such as specific rotation, assay purity, and impurity profiles meet the specified limits. The following table outlines the critical quality attributes associated with our standard grade D-Proline, demonstrating our commitment to transparency and reliability.

ParameterSpecification
AppearanceWhite crystalline powder
Assay98.5% to 101.0%
Specific Rotation+83.5 to +86.0 degrees
Loss on DryingNot more than 0.4%
Residue on IgnitionNot more than 0.1%
ChlorideNot more than 0.03%
Heavy MetalsNot more than 10ppm
L-Isomer ImpurityNot more than 0.5%

Industrial Applications

The versatility of D-Proline extends across multiple sectors, primarily focusing on pharmaceutical intermediates and nutraceutical formulations. In drug discovery, it serves as a key starting material for the asymmetric synthesis of various therapeutic agents. Its ability to act as a chiral catalyst or auxiliary facilitates the creation of enantiomerically pure compounds, which is critical for regulatory approval and drug efficacy. Furthermore, D-Proline is utilized in the production of peptide-based drugs, where sequence specificity determines biological activity. Beyond pharmaceuticals, it finds application as a specialized additive in food and feed industries, contributing to nutritional profiles. The compound is also employed in the asymmetric self-condensation of beta-ionylideneacetaldehyde, showcasing its utility in synthesizing retinal and related vitamin A derivatives. Our clients rely on this material for developing next-generation treatments and high-performance chemical products.

Quality Assurance and Storage

We maintain a robust quality management system to guarantee product integrity from synthesis to shipment. Our packaging options are designed to protect the material from moisture and contamination, typically supplied in 25kg drums or customized according to client logistics requirements. Proper storage is essential to maintain the physicochemical properties of D-Proline. We recommend storing the product in a cool, dry, and well-ventilated area, keeping containers tightly closed when not in use. Our team provides full technical support, including Certificates of Analysis and Method of Analysis for every shipment, ensuring transparency and compliance with your quality control protocols. Partner with us for a reliable supply chain of premium chiral building blocks.