Fmoc-Ala-Ala-OH

Product Overview

Fmoc-Ala-Ala-OH is a highly specialized dipeptide building block designed for advanced peptide synthesis applications. As a protected amino acid derivative, it features the Fluorenylmethyloxycarbonyl (Fmoc) group at the N-terminus, providing exceptional stability during solid-phase peptide synthesis (SPPS). This compound consists of two L-alanine residues linked by a peptide bond, serving as a critical structural unit in the construction of complex pharmaceutical peptides and therapeutic proteins. Our manufacturing process ensures rigorous quality control, making this product suitable for both research and development scale-ups as well as large-scale commercial production.

The Fmoc protection strategy allows for mild deprotection conditions, preserving the integrity of sensitive side chains and preventing racemization during coupling reactions. This makes Fmoc-Ala-Ala-OH an indispensable reagent for medicinal chemists and process engineers focused on high-efficiency peptide assembly. The alanine side chain offers a balanced steric profile, facilitating smooth coupling kinetics while maintaining structural rigidity in the growing peptide chain.

Technical Specifications

Our quality assurance team verifies every batch against strict international standards. The following parameters represent the typical specifications for this high-grade chemical intermediate.

Key Advantages

• High Chemical Purity: Rigorously tested via HPLC to ensure minimal impurities for consistent reaction outcomes.
• Stable Protection Group: The Fmoc group offers superior stability under acidic conditions while being easily removable with bases.
• Low Racemization Risk: Optimized synthesis routes minimize epimerization, ensuring stereochemical integrity.
• Scalable Supply: Capable of meeting demands from gram-scale research to kilogram-level production.
• Comprehensive Documentation: Full traceability with batch-specific Certificates of Analysis.

Industrial Applications

This dipeptide derivative is primarily utilized in the pharmaceutical industry for the synthesis of bioactive peptides. It serves as a fundamental building block in the development of novel therapeutics, including hormone analogs and enzyme inhibitors. Additionally, it is widely used in academic research for structure-activity relationship (SAR) studies. The high purity grade ensures reliable data generation during preclinical trials and process optimization phases. Compatible with standard coupling reagents such as HBTU and HATU, it integrates seamlessly into existing workflows.

Storage and Handling

To maintain optimal quality, Fmoc-Ala-Ala-OH should be stored in a tightly closed container at temperatures below -15 degrees Celsius. The material is hygroscopic and should be kept in a cool, dry environment away from direct sunlight and moisture. Proper handling procedures include using dry solvents during coupling reactions to prevent hydrolysis. We provide comprehensive documentation, including Certificates of Analysis (COA) and Material Safety Data Sheets (MSDS), to support regulatory compliance and quality assurance protocols. Global shipping options are available to ensure timely delivery for your production schedules.