Fmoc-D-Arg(Pbf)-OH

Product Overview

Fmoc-D-Arg(Pbf)-OH is a highly specialized protected amino acid derivative designed for use in advanced solid-phase peptide synthesis (SPPS). As a critical building block, this compound features the Fmoc (9-fluorenylmethoxycarbonyl) protecting group on the alpha-amino function and the Pbf (2,2,4,6,7-pentamethyl-2,3-dihydrobenzofuran-5-sulfonyl) group on the guanidine side chain. This specific configuration ensures exceptional stability during chain elongation while allowing for efficient deprotection under standard acidic cleavage conditions.

Our manufacturing process adheres to strict quality control protocols to ensure consistent optical purity and chemical integrity. The D-configuration of the arginine residue is particularly valuable for researchers developing peptide therapeutics that require enhanced metabolic stability or specific conformational properties. By incorporating D-amino acids, pharmaceutical scientists can modulate the biological activity and half-life of peptide candidates during the early stages of drug discovery.

Key Specifications

We maintain rigorous standards for all our peptide building blocks to support reproducible research and development outcomes. The following table outlines the typical physical and chemical properties verified through our internal quality assurance laboratory.

Industrial Applications

This protected amino acid is primarily utilized in the pharmaceutical and biotechnology sectors for the synthesis of complex peptide structures. It serves as an essential reagent in the construction of peptide libraries, hormone analogs, and investigative therapeutic agents. The Pbf protecting group is favored in modern synthesis strategies due to its resistance to premature cleavage and its compatibility with various coupling reagents.

• Solid-phase peptide synthesis (SPPS) for drug discovery.
• Production of peptide hormones and signaling molecules.
• Development of metabolically stable peptide analogs.
• Research into protein-protein interaction inhibitors.

Quality Assurance and Storage

To maintain the integrity of Fmoc-D-Arg(Pbf)-OH, proper storage conditions are essential. The compound should be kept in a tightly sealed container under refrigeration between 2 and 8 degrees Celsius, protected from moisture and light. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing HPLC chromatograms, optical rotation data, and elemental analysis results. Our global supply chain ensures that materials are shipped with appropriate cold-chain packaging to guarantee arrival in optimal condition.