Fmoc-HoArg-OH

Product Overview

Fmoc-HoArg-OH, chemically known as (2S)-6-(diaminomethylideneamino)-2-(9H-fluoren-9-ylmethoxycarbonylamino)hexanoic acid, serves as a vital protected amino acid derivative within the pharmaceutical and biotechnology sectors. This compound features a fluorenylmethyloxycarbonyl (Fmoc) protecting group on the alpha-amino function, making it exceptionally suitable for solid-phase peptide synthesis (SPPS) strategies. The homoarginine side chain provides unique structural properties that are essential for designing specific peptide sequences with enhanced biological activity or stability.

Our manufacturing facility produces this reagent under stringent quality control protocols to ensure consistency across batches. As a key building block, it facilitates the incorporation of homoarginine residues into complex peptide chains without premature side reactions. The high level of purity guarantees minimal impurities that could otherwise complicate downstream purification processes or affect the efficacy of the final therapeutic peptide.

Technical Specifications

Industrial Applications

This protected amino acid is primarily utilized in the research and development of novel peptide-based therapeutics. It is an indispensable component for medicinal chemists working on hormone analogs, enzyme inhibitors, and receptor ligands where the extended side chain of homoarginine offers distinct advantages over standard arginine residues. The Fmoc protection strategy allows for orthogonal deprotection conditions, enabling the synthesis of intricate peptide architectures including cyclic peptides and peptidomimetics.

Beyond pharmaceutical drug discovery, this compound finds application in the production of diagnostic reagents and biochemical research tools. Laboratories requiring custom peptide synthesis rely on high-quality building blocks like Fmoc-HoArg-OH to ensure reproducible results in binding assays and structural biology studies. Its compatibility with standard coupling reagents makes it a versatile choice for both manual and automated synthesis platforms.

Quality Assurance and Storage

We maintain a robust quality management system to verify the identity and purity of every batch. Comprehensive testing includes High-Performance Liquid Chromatography (HPLC), Nuclear Magnetic Resonance (NMR), and Mass Spectrometry (MS) analysis. A Certificate of Analysis (COA) is provided with each shipment, detailing all relevant test results against established specifications. Our commitment to industrial purity ensures that clients receive materials ready for immediate use in sensitive synthetic procedures.

Proper storage is critical to maintain the stability of this hygroscopic compound. Containers should remain tightly closed and stored in a cool, dry environment away from direct sunlight and moisture. We recommend keeping the material in a desiccator if prolonged storage is anticipated. Packaging options include 25 kg drums or customized solutions based on specific client requirements, ensuring safe global transportation. For bulk pricing inquiries or technical support regarding synthesis routes, our team of experts is available to assist with your project needs.