Fmoc-O-tert-butyl-L-tyrosine

Product Overview

Fmoc-O-tert-butyl-L-tyrosine is a highly specialized protected amino acid derivative essential for modern peptide chemistry. Designed specifically for solid-phase peptide synthesis (SPPS), this compound features a fluorenylmethoxycarbonyl (Fmoc) group on the alpha-amino function and a tert-butyl group protecting the phenolic hydroxyl side chain. This dual protection strategy ensures high fidelity during chain elongation while preventing unwanted side reactions at the tyrosine residue.

Our manufacturing process adheres to rigorous quality standards, delivering a product with exceptional optical purity and minimal impurities. This building block is indispensable for pharmaceutical research, peptide drug development, and the production of complex biological sequences where tyrosine incorporation is required.

Key Features and Advantages

• High Chemical Purity: Assay results consistently exceed 99.5%, ensuring reliable reaction kinetics.
• Superior Optical Purity: Enantiomeric excess is strictly controlled to prevent racemization during coupling.
• Optimized Protection: The O-tert-butyl group is stable under basic Fmoc deprotection conditions but easily removed during final acid cleavage.
• Low Impurity Profile: Strict limits on related substances such as Fmoc-OH and free amino acids guarantee clean synthesis outcomes.
• Consistent Supply: Manufactured in bulk quantities with stable inventory for large-scale production needs.

Technical Specifications

Quality control is paramount in peptide building block supply. Each batch undergoes comprehensive analysis using HPLC, polarimetry, and loss on drying tests. The following table summarizes the critical quality attributes verified for this product:

Storage and Handling

To maintain stability and prolong shelf life, Fmoc-O-tert-butyl-L-tyrosine should be stored in a cool, dry environment. The recommended storage temperature is between 2-8°C. The compound is stable under normal temperatures and pressures but should be protected from moisture and strong oxidizing agents. When handling, standard laboratory safety protocols apply, including the use of gloves and eye protection to prevent irritation. Proper storage ensures the reagent remains ready for immediate use in sensitive coupling reactions without degradation.

Industrial Applications

This protected amino acid is primarily utilized in the synthesis of therapeutic peptides, diagnostic agents, and research compounds. It serves as a critical monomer in the assembly of sequences requiring tyrosine residues with protected side chains. The high purity levels make it suitable for GMP-grade peptide manufacturing, supporting the development of next-generation biologics and pharmaceutical intermediates.