N-Cbz-L-glutamic Acid 5-tert-Butyl Ester

Product Overview

N-Cbz-L-glutamic Acid 5-tert-Butyl Ester is a highly specialized protected amino acid derivative essential for modern pharmaceutical synthesis and peptide chemistry. As a key building block, this compound features a carboxybenzyl (Cbz) protecting group on the alpha-amino function and a tert-butyl ester protection on the gamma-carboxyl side chain. This specific protection strategy ensures orthogonality during solid-phase peptide synthesis (SPPS) and solution-phase reactions, allowing chemists to selectively deprotect groups without compromising the integrity of the molecular structure.

Our manufacturing facility produces this intermediate under strict quality control protocols to ensure consistent batch-to-batch reliability. The compound is particularly valued for its stability under various reaction conditions, making it an ideal choice for constructing complex peptide sequences used in therapeutic development.

Technical Specifications

We adhere to rigorous analytical standards to guarantee the performance of our chemical building blocks. The following table outlines the critical physical and chemical parameters for this product:

Industrial Applications

This protected glutamic acid derivative serves as a fundamental component in the synthesis of bioactive peptides and protein mimetics. Its primary applications include:

• Solid-Phase Peptide Synthesis (SPPS): The tert-butyl ester group is acid-labile, allowing for clean removal during final cleavage steps while maintaining stability during base-mediated coupling.
• Pharmaceutical Intermediates: Used extensively in the production of peptide-based drugs where glutamic acid residues require side-chain protection.
• Chemical Biology Research: Employed in the development of probes and labeled compounds for studying cellular mechanisms.
• Custom Peptide Manufacturing: Suitable for large-scale production processes requiring high purity starting materials.

Quality Assurance and Storage

Every batch of N-Cbz-L-glutamic Acid 5-tert-Butyl Ester is accompanied by a comprehensive Certificate of Analysis (COA) detailing test results against internal specifications. We utilize advanced chromatographic methods to verify purity and structural identity. To maintain optimal stability, the product should be stored in tightly closed containers at temperatures between 2-8°C. The material must be kept in a cool, dry environment away from direct sunlight and moisture to prevent hydrolysis of the ester bond. Our packaging options include 25 kg drums or customized solutions based on specific client logistics requirements.