tert-Butyl L-valinate

Product Overview

tert-Butyl L-valinate is a highly specialized protected amino acid derivative extensively utilized in the field of organic synthesis and pharmaceutical manufacturing. As a crucial building block, this compound features a tert-butyl ester protection group on the carboxyl terminus of L-valine, making it indispensable for controlled peptide chain elongation. Our facility produces this intermediate under strict quality management systems to ensure consistency and reliability for downstream processes.

The chemical structure provides excellent stability during various synthetic reactions while allowing for selective deprotection when required. This balance makes it a preferred choice for chemists developing complex active pharmaceutical ingredients (APIs) and novel peptide therapeutics. We commit to delivering material that meets rigorous international standards for purity and physical properties.

Technical Specifications

Physical and Chemical Properties

Understanding the physical characteristics of tert-Butyl L-valinate is essential for process optimization. The compound exhibits a density of approximately 0.936 g/cm3, facilitating accurate dosing in reaction vessels. With a boiling point of 241.7ºC at 760 mmHg, it demonstrates thermal stability suitable for various synthesis conditions. The flash point is recorded at 100ºC, indicating standard safety handling protocols should be followed during storage and manipulation. Additionally, the refractive index of 1.441 serves as a key identifier for quality control verification during batch release testing.

Industrial Applications

This protected amino acid ester serves primarily as a pharmaceutical intermediate. It is widely employed in the solid-phase and solution-phase synthesis of peptides. The tert-butyl group offers orthogonality to other common protecting groups, allowing for sophisticated synthetic strategies in drug discovery. Researchers utilize this building block to construct specific sequences required for biological activity studies. Furthermore, it acts as a precursor in the manufacturing of larger peptide-based drugs where valine residues are critical for structural integrity and function.

Quality Assurance and Packaging

We prioritize product integrity from synthesis to shipment. Each batch undergoes comprehensive analysis including HPLC, NMR, and physical property testing to confirm compliance with specifications. A Certificate of Analysis (COA) is provided with every order to ensure traceability and quality assurance. The standard packaging consists of 25 kg drums, designed to protect the material from moisture and contamination. Customized packaging solutions are available upon request to meet specific logistical requirements of our global clientele.

Storage and Handling

To maintain optimal stability, tert-Butyl L-valinate should be stored at -15ºC. It is imperative to keep the container tightly closed when not in use. The material must be kept in a tight dispenser and stored in a cool, dry place away from direct sunlight and sources of ignition. Proper handling procedures ensure that the chemical properties remain unchanged over time, guaranteeing performance in your synthesis workflows. Our team is available to provide technical support regarding safe handling and integration into your specific manufacturing processes.