Z-Glu(OtBu)-OH

Product Overview

Z-Glu(OtBu)-OH is a highly specialized protected amino acid derivative that serves as a fundamental building block in the realm of advanced peptide synthesis and organic chemistry. This compound features a glutamic acid backbone where the alpha-amino group is protected by a benzyloxycarbonyl (Z or Cbz) group, and the gamma-carboxyl group is protected as a tert-butyl ester. This dual protection strategy is critical for ensuring chemoselectivity during multi-step synthesis processes, preventing unwanted side reactions at both the amine and side-chain carboxyl positions.

Our manufacturing facility produces this intermediate under strict quality control standards to ensure consistency across batches. The compound is particularly valued in the pharmaceutical and biotechnology sectors for its stability and reliability in solid-phase peptide synthesis (SPPS) and solution-phase synthesis. By utilizing high-grade raw materials and optimized crystallization processes, we deliver a product that meets the rigorous demands of modern drug discovery and development pipelines.

Key Specifications

Industrial Applications

This protected glutamic acid derivative is primarily employed as a monomer in the construction of complex peptide chains. The Z group offers robust protection that can be removed under specific hydrogenolysis conditions, while the tert-butyl ester is acid-labile, allowing for orthogonal deprotection strategies. This versatility makes it an indispensable reagent for synthesizing bioactive peptides, hormonal analogs, and custom research compounds.

• Solid-Phase Peptide Synthesis (SPPS): Ideal for stepwise chain elongation.
• Solution-Phase Synthesis: Suitable for fragment condensation approaches.
• Pharmaceutical Intermediates: Used in the production of peptide-based therapeutics.
• Research and Development: Essential for laboratory-scale organic synthesis projects.

Quality Assurance and Storage

Quality is paramount in chemical manufacturing. Each batch of Z-Glu(OtBu)-OH undergoes comprehensive analytical testing, including HPLC, NMR, and melting point analysis, to verify identity and purity. We provide a Certificate of Analysis (COA) with every shipment to ensure transparency and compliance with your internal quality standards. Proper handling is essential to maintain the integrity of the product.

To prevent degradation via hydrolysis or oxidation, the material should be stored in a tightly closed container at -20°C in a cool, dry environment. Exposure to moisture and strong light should be minimized. We offer flexible packaging options, including 25 kg drums or customized packaging according to specific customer requirements, ensuring safe global delivery. Our logistics network supports worldwide shipping, providing reliable supply chain solutions for laboratories and manufacturing plants alike.