1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE): A Key Helper Lipid for Advanced Gene Delivery and Pharmaceutical Formulations
Discover the critical role of DOPE in enhancing gene delivery and formulating advanced pharmaceutical products. Explore its applications in transfection and beyond.
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1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine
As a premier supplier in China, we offer 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE), a crucial synthetic phospholipid. DOPE acts as an essential helper lipid in various advanced applications, particularly in the realm of gene delivery. Its unique properties allow it to facilitate DNA-liposome complex transport across cell membranes, making it a cornerstone for effective gene therapy and transfection studies. We are committed to providing high-quality pharmaceutical intermediates to meet the evolving needs of the biotechnology and pharmaceutical sectors.
- Facilitate DNA-liposome complex transport: Our high-purity DOPE is instrumental in creating stable liposomal formulations that efficiently transport genetic material across cellular barriers, a key aspect of advanced gene delivery.
- Enhance DNA transfection efficiency: When used in conjunction with cationic phospholipids, DOPE significantly boosts the efficiency of DNA transfection, offering a robust non-viral method for gene delivery. This makes it a sought-after excipient for researchers and developers.
- Synthetic analog of naturally occurring PE: As a synthetic analog of naturally occurring phosphatidylethanolamine, DOPE offers consistent quality and performance, ensuring reliability in your research and development processes.
- Crucial for mRNA vaccines: DOPE plays a role in stabilizing vaccine formulations and aiding their uptake into cells, highlighting its importance in the development of next-generation therapeutics.
Key Advantages Offered by DOPE
Enhanced Gene Delivery
Leverage the power of DOPE to achieve superior gene delivery efficiency in your research. Its ability to form stable lipoplexes with nucleic acids is critical for advancing gene therapy protocols.
Improved Transfection Rates
Achieve higher transfection rates in your cellular studies by incorporating DOPE into your lipid formulations. This contributes to more reliable and reproducible results in gene editing and delivery research.
Versatile Pharmaceutical Applications
As a versatile pharmaceutical excipient, DOPE is integral to the development of novel drug delivery systems, including advanced liposomes and nanoparticles for targeted therapies.
Key Applications
Gene Delivery
DOPE is a fundamental component in creating lipid nanoparticles and liposomes designed for efficient gene delivery, vital for gene therapy and vaccine development.
DNA Transfection Studies
In research settings, DOPE is widely used to enhance the efficacy of DNA transfection, enabling more successful gene expression studies and research into genetic diseases.
Liposome Formulation
Its unique phase behavior makes DOPE an ideal helper lipid for formulating stable and functional liposomes used in drug delivery, imaging, and diagnostics.
Pharmaceutical Research
The broad applicability of DOPE in creating advanced delivery systems makes it a key ingredient for researchers developing next-generation pharmaceuticals and therapeutic agents.