Daclizumab: Understanding its Role and Withdrawal in MS Treatment
Explore the science behind Daclizumab, its application in organ transplantation and multiple sclerosis, and the critical safety concerns that led to its market withdrawal.
Get a Quote & SampleKey Insights into Daclizumab's Application and Safety
Daclizumab
Daclizumab, a potent humanized monoclonal antibody, functions by targeting the IL-2 receptor alpha subunit (CD25). Initially recognized for its efficacy in preventing acute organ rejection in kidney transplantation, it was later developed for treating relapsing forms of multiple sclerosis. As a specialized pharmaceutical intermediate, Daclizumab is of significant interest to researchers and drug developers worldwide. Manufacturers in China are key suppliers for such advanced biomolecules.
- Mechanism of Action: Daclizumab reversibly binds to CD25, inhibiting the interaction of IL-2 with its high-affinity receptor, thereby modulating immune responses. This makes it a critical component for understanding autoimmune pathways.
- Therapeutic Applications: Initially used to prevent organ rejection, its subsequent use in relapsing multiple sclerosis showcased its potential in managing chronic inflammatory conditions.
- Market Withdrawal: Due to severe safety concerns, including inflammatory brain disorders like encephalitis and liver toxicity, Daclizumab was voluntarily withdrawn from the global market by its manufacturers.
- Research Significance: Despite its market withdrawal for clinical use, Daclizumab remains a vital tool for scientific research into immune system modulation and related diseases, making it a sought-after product for pharmaceutical research suppliers.
Understanding Daclizumab's Impact
Targeted Immune Modulation
Daclizumab's ability to selectively target the CD25 antigen offers precise control over specific immune cell populations, crucial for research in immunology and autoimmune disease models.
Dual Application Potential
Its history in both organ transplantation and multiple sclerosis treatment highlights its versatility as a therapeutic agent, offering valuable insights for drug developers seeking to buy or source similar compounds from reliable manufacturers.
Safety Profile Insights
The documented safety issues, including brain inflammation and hepatotoxicity, provide critical data for ongoing pharmaceutical research and development, guiding the design of safer, next-generation biologics. Researchers can purchase Daclizumab for study to understand these adverse events.
Key Application Areas
Organ Transplantation
Daclizumab was utilized to prevent acute rejection episodes in patients receiving organ transplants, underscoring its role in immunosuppressive therapy. Sourcing high-quality Daclizumab from a trusted supplier is essential for preclinical studies.
Multiple Sclerosis Research
Although withdrawn for clinical use, Daclizumab's mechanism of action against autoimmune responses in MS continues to be a subject of research, offering pathways for new treatment strategies. Scientists often buy this compound to investigate its cellular effects.
Immunology Research
As a well-characterized monoclonal antibody, Daclizumab is an invaluable tool for researchers studying T-cell activation, immune tolerance, and the complex pathways involved in various immunological disorders.
Pharmacological Studies
Its availability from reputable manufacturers allows pharmacologists to study its pharmacokinetics, pharmacodynamics, and potential off-target effects, contributing to the broader understanding of antibody-based therapeutics.