DOTA-Tris(tBu) Ester: Advanced Chelator for Radiopharmaceuticals and Molecular Imaging
Discover the indispensable role of DOTA-Tris(tBu) Ester (CAS: 137076-54-1) in cutting-edge radiopharmaceutical development and molecular imaging. As a leading manufacturer and supplier in China, we provide high-purity DOTA-Tris(tBu) Ester to advance your research and therapeutic applications.
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DOTA-Tris(tBu) Ester: A Key Bifunctional Chelator
DOTA-Tris(tBu) Ester (CAS: 137076-54-1) is a critical bifunctional chelator, vital for the precise attachment of metal ions to biomolecules. Its unique structure, featuring the stable DOTA macrocycle with selectively protected carboxylate arms, makes it an ideal intermediate for advanced applications in molecular imaging and targeted radionuclide therapy. As a trusted supplier, we ensure competitive pricing for this essential compound.
- Explore the Power of DOTA Macrocycle: Learn how this 12-membered cyclic tetraamine framework provides exceptional stability for metal complexes.
- Strategic Protection for Synthesis: Understand the role of tert-butyl ester protection in enabling selective bioconjugation.
- High Purity from a Reliable Manufacturer: Trust our commitment to quality and availability, essential for your research and production needs.
- Advance Radiopharmaceutical Development: Discover how this chelator facilitates diagnostic imaging (PET/SPECT) and theranostics.
Key Advantages of DOTA-Tris(tBu) Ester
Exceptional Stability for In Vivo Applications
The DOTA macrocycle forms highly stable and kinetically inert complexes with a wide range of metal ions. This prevents premature dissociation of radionuclides in vivo, crucial for minimizing off-target accumulation and enhancing therapeutic efficacy, making it a preferred choice when you buy DOTA-tris(tBu) ester.
Versatile Radiometal Compatibility
DOTA-Tris(tBu) Ester can chelate diverse radiometals, offering flexibility for various diagnostic imaging modalities (PET, SPECT) and therapeutic strategies (beta- or alpha-emitters). This versatility is key for researchers seeking robust solutions for targeted radionuclide therapy.
Precision in Bioconjugation
The selectively unprotected carboxylic acid group allows for precise covalent attachment to biomolecules like peptides and antibodies via amide bond formation. This capability is fundamental when considering the purchase of DOTA-tris(tBu) ester for advanced bioconjugation strategies.
Applications Driving Medical Innovation
Radiopharmaceutical Development
DOTA-Tris(tBu) Ester is a cornerstone in creating diagnostic imaging agents (PET/SPECT) and therapeutic radiopharmaceuticals, enabling precise patient treatment and monitoring.
Molecular Imaging Probes
It serves as a critical building block for developing sophisticated probes that visualize biological processes at the molecular level, aiding in early disease detection.
Targeted Radionuclide Therapy
Its bifunctional nature allows for targeted delivery of therapeutic radioisotopes directly to disease sites, minimizing systemic toxicity and maximizing treatment effectiveness.
Bioconjugation and Ligand Design
This intermediate is essential for synthesizing complex DOTA derivatives and conjugating them with biomolecules, allowing for the fine-tuning of pharmacokinetic properties and targeting specificity.