Exatecan Mesylate Hydrate: A Potent Topoisomerase I Inhibitor for Pharmaceutical Intermediates
Discover Exatecan Mesylate Hydrate (CAS 197720-53-9), a highly potent topoisomerase I inhibitor and crucial pharmaceutical intermediate. Explore its advanced applications in oncology research, antibody-drug conjugates (ADCs), and cutting-edge drug delivery systems. We are a trusted supplier of high-purity Exatecan Mesylate Hydrate, offering competitive pricing and reliable sourcing for your demanding research needs.
Get a Quote & SampleUnlocking Advanced Cancer Therapies with Exatecan Mesylate Hydrate
Exatecan Mesylate Hydrate (CAS 197720-53-9)
As a leading manufacturer and supplier of pharmaceutical intermediates in China, we offer Exatecan Mesylate Hydrate, a critical component for developing next-generation anticancer agents. This potent topoisomerase I inhibitor is a semisynthetic derivative of camptothecin, known for its high purity and efficacy in stabilizing the cleavable complex between topoisomerase I and DNA, thereby inducing apoptosis. Explore our competitive pricing and bulk order options for this vital research compound.
- Potent Topoisomerase I Inhibition: Exatecan Mesylate Hydrate (CAS 197720-53-9) effectively stabilizes the topoisomerase I-DNA cleavable complex, leading to DNA strand breaks and cell death, crucial for antineoplastic activity.
- Advanced Payload for ADCs: This compound serves as a highly effective cytotoxic payload in antibody-drug conjugates (ADCs), such as those employing a derivative like DXd, offering enhanced tumor targeting and potency.
- Superior Membrane Permeability: Exhibiting higher membrane permeability than other camptothecin derivatives, it contributes to a stronger bystander killing effect in targeted therapies, making it a sought-after pharmaceutical intermediate.
- High Purity and Reliability: We are a trusted Exatecan Mesylate Hydrate supplier, ensuring high purity (99%) and consistent quality for your critical pharmaceutical research and manufacturing processes.
Key Advantages of Exatecan Mesylate Hydrate
Enhanced Potency as a Topoisomerase I Inhibitor
Exatecan Mesylate Hydrate demonstrates superior potency compared to other camptothecin analogues like SN-38 and topotecan. Its ability to induce DNA strand breaks at lower concentrations makes it an invaluable pharmaceutical intermediate for potent anticancer drug development.
Versatile Application in Targeted Therapies
As a key cytotoxic payload, Exatecan Mesylate Hydrate is instrumental in the design of advanced Antibody-Drug Conjugates (ADCs) and Peptide-Drug Conjugates (PDCs). Its properties enable effective bystander killing, enhancing therapeutic outcomes against heterogeneous tumors. Purchase this essential intermediate for your ADC manufacturing.
Optimized for Advanced Drug Delivery Systems
Our Exatecan Mesylate Hydrate is synthesized to meet stringent quality standards, making it suitable for advanced drug delivery platforms including PEGylation and prodrug strategies. Secure a reliable supplier for your high-purity needs.
Applications of Exatecan Mesylate Hydrate
Oncology Drug Development
Exatecan Mesylate Hydrate is a critical pharmaceutical intermediate used in the discovery and development of novel anticancer agents, particularly those targeting DNA replication and cell proliferation pathways.
Antibody-Drug Conjugate (ADC) Payloads
It serves as a potent cytotoxic payload in ADCs, enabling targeted delivery to cancer cells with improved efficacy and reduced systemic toxicity. Buy high-quality Exatecan Mesylate Hydrate for your ADC pipeline.
Preclinical Research & In Vitro Studies
Researchers utilize Exatecan Mesylate Hydrate for in vitro and in vivo studies to evaluate new therapeutic strategies, mechanism of action, and resistance profiles of topoisomerase I inhibitors.
Pharmaceutical Intermediate Manufacturing
As a key intermediate, its consistent quality and reliable supply are essential for pharmaceutical manufacturers involved in producing advanced APIs. Contact us for bulk purchase inquiries.