Fmoc-Asp(OMpe)-OH: A High-Purity Building Block for Advanced Peptide Synthesis
Unlock superior peptide purity and simplify synthesis with this advanced aspartic acid derivative.
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Fmoc-Asp(OMpe)-OH
Fmoc-Asp(OMpe)-OH is a premium Fmoc-protected aspartic acid derivative designed for demanding peptide synthesis applications. Its key advantage lies in the incorporation of the OMpe ester protecting group on the beta-carboxyl of aspartic acid. This sterically hindered group significantly minimizes the notoriously problematic aspartimide formation, a common side reaction that compromises peptide purity and complicates downstream purification. By preventing this side reaction, Fmoc-Asp(OMpe)-OH enables the creation of higher purity crude peptides, thereby streamlining the time- and cost-intensive purification processes. This makes it an invaluable component for researchers and manufacturers focused on obtaining top-quality peptides.
- High Purity Peptide Building Block: Utilizing Fmoc-Asp(OMpe)-OH in your peptide synthesis strategy ensures a higher final product purity by mitigating side reactions.
- Suppresses Aspartimide Formation: The unique OMpe ester protecting group on the beta-carboxyl of aspartic acid effectively prevents the formation of aspartimide, a common impurity.
- Facilitates Purification Processes: By reducing side products, this derivative simplifies and speeds up the purification of synthesized peptides, saving valuable time and resources.
- Essential for Custom Peptide Synthesis Reagent: As a key component in custom peptide synthesis, its reliability and effectiveness are critical for achieving precise peptide sequences.
Key Advantages
Enhanced Peptide Purity
The strategic use of the OMpe ester protecting group in Fmoc-Asp(OMpe)-OH leads to substantially reduced aspartimide byproduct, yielding cleaner peptide sequences.
Streamlined Workflow
By minimizing side reactions, the need for extensive purification steps is reduced, leading to a more efficient and cost-effective peptide synthesis workflow.
Reliable Fmoc Strategy Component
As a critical Fmoc protected aspartic acid derivative, it integrates seamlessly into established Fmoc-based solid-phase peptide synthesis protocols.
Key Applications
Peptide Synthesis
A crucial building block for synthesizing peptides with high fidelity, leveraging the Fmoc strategy for controlled chain elongation.
Peptidomimetic Design
Enables the construction of peptidomimetics where precise structural integrity is paramount, supported by reliable peptide synthesis reagents.
Protein Engineering
Facilitates the creation of modified proteins for research, benefiting from the improved purity offered by this aspartic acid derivative.
Biochemical Research
Essential for researchers investigating enzyme inhibition, protein folding, and other complex biological processes that rely on pure peptide samples.