YM 26734: A Potent Inhibitor of Secretory Phospholipase A2 for Inflammatory Research
Explore the mechanism and applications of a key compound in understanding and modulating inflammatory pathways.
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YM 26734
YM 26734 is a highly specific chemical compound that functions as a competitive inhibitor of secretory phospholipase A2 (sPLA2). Its ability to modulate inflammatory responses makes it a valuable tool in biochemical and pharmaceutical research.
- Understanding Secretory Phospholipase A2 Inhibition: YM 26734 provides researchers with a precise tool to investigate the role of various sPLA2 subtypes in biological processes.
- Mechanism of Action in Inflammation Research: By competitively inhibiting sPLA2 enzymes, YM 26734 helps elucidate the pathways leading to inflammatory responses, aiding in the development of novel therapeutic strategies.
- Broad Inhibitory Profile: This compound exhibits potent inhibition across multiple sPLA2 subtypes, including sPLA2-X, -IIA, -IID, -V, and -IIE, offering versatility in experimental design.
- Specificity in Biological Assays: YM 26734 demonstrates minimal activity against other enzymes like cytosolic PLA2, cyclooxygenase, and lipoxygenase, ensuring focused research outcomes.
Key Advantages
Precise Inflammatory Pathway Modulation
Leverage the specificity of YM 26734 to precisely target and study the impact of secretory phospholipase A2 inhibition on inflammatory cascades.
Tool for Preclinical Inflammation Studies
Utilize YM 26734 in models like TPA-induced mouse ear edema to investigate its capacity to ameliorate local inflammatory responses, as demonstrated in research.
Versatile Research Applications
Benefit from the compound's broad inhibitory profile against various sPLA2 subtypes, enabling diverse experimental approaches in biochemical research.
Key Applications
Inflammation Research
YM 26734 serves as a critical reagent for investigating the complex mechanisms of inflammation by targeting secretory phospholipase A2 activity.
PLA2 Enzyme Studies
Researchers can utilize YM 26734 to understand the specific roles and functions of different PLA2 isoforms in various biological contexts.
Drug Discovery and Development
As a potent sPLA2 inhibitor, YM 26734 can serve as a lead compound or research tool in the discovery of novel anti-inflammatory therapeutics.
Biochemical Assays
The compound's well-defined inhibitory activity makes it suitable for use in biochemical assays to screen or validate other potential PLA2 modulators.