4,4'-Dimethoxytrityl chloride

Product Overview

4,4'-Dimethoxytrityl chloride, commonly abbreviated as DMT-Cl, is a highly specialized organic reagent essential for modern pharmaceutical and biotechnological synthesis. Identified by CAS number 40615-36-9, this compound functions primarily as a protecting group for the 5'-hydroxy position in nucleosides. Our manufacturing process ensures exceptional stability and reactivity, making it a preferred choice for researchers and industrial producers engaged in oligonucleotide synthesis. The compound is characterized by its distinct light pink powder appearance and high molecular integrity.

Key Specifications

We adhere to rigorous quality assurance protocols to guarantee that every batch meets international standards for fine chemical reagents. The following table outlines the critical physical and chemical parameters verified through our internal laboratory testing and third-party validation.

Industrial Applications

The primary application of 4,4'-Dimethoxytrityl chloride lies in the field of nucleic acid chemistry. It is indispensable for the synthesis of DNA and RNA oligonucleotides, where it protects the 5'-hydroxyl group during phosphoramidite coupling cycles. This protection prevents unwanted side reactions, ensuring high coupling efficiency and final product purity. Beyond nucleosides, this reagent is occasionally utilized in the synthesis of complex pharmaceutical intermediates requiring selective hydroxyl protection. Its reliability in harsh synthetic conditions makes it a staple in both academic research laboratories and large-scale production facilities.

Quality and Safety Assurance

As a responsible manufacturer, we prioritize safety and consistency. Our production facilities operate under strict environmental controls to maintain the integrity of the chemical structure. Each shipment is accompanied by a Certificate of Analysis (COA) detailing batch-specific test results. We recommend handling this material in a well-ventilated environment using appropriate personal protective equipment. The product is stable when stored correctly, maintaining its efficacy over extended periods without significant degradation.

Packaging and Storage

To preserve quality during transit, 4,4'-Dimethoxytrityl chloride is packaged in secure 25 kg drums. Custom packaging solutions are available upon request to meet specific logistical requirements. Storage should be in a cool, ventilated area away from direct sunlight and moisture. Proper storage conditions are critical to preventing hydrolysis, which can compromise the reactivity of the chloride group. We offer global shipping options with comprehensive documentation to ensure smooth customs clearance for international buyers.