Speciality Chemicals

Fluoro(trimethyl)silane

  • CAS No.420-56-4
  • GradeIndustrial / Pharmaceutical
  • Availability● In Stock

High-purity Fluoro(trimethyl)silane (CAS 420-56-4) is a versatile silylating agent designed for advanced organic synthesis and pharmaceutical manufacturing processes.

Request a Quote & Full COA

Product Technical Details

Product Overview

Fluoro(trimethyl)silane, frequently recognized in chemical literature as Trimethylsilyl fluoride, stands as a pivotal reagent within the realm of advanced organic synthesis and fine chemical manufacturing. This specialized silane compound is engineered to serve as a potent source of fluoride ions and trimethylsilyl groups, facilitating complex molecular transformations required in the development of pharmaceutical intermediates and high-performance materials. Our production processes adhere to stringent international quality standards, ensuring consistent reliability for research and industrial scale applications.

As a volatile liquid with distinct reactivity profiles, this chemical enables precise desilylation reactions and the introduction of fluorine motifs into organic frameworks. The compound is particularly valued for its ability to act as a mild yet effective fluorinating agent under controlled conditions, making it indispensable for laboratories and production facilities focused on medicinal chemistry and polymer science.

Key Specifications

ParameterSpecification
CAS Number420-56-4
Molecular FormulaC3H9FSi
Molecular Weight92.19 g/mol
AppearanceColorless clear liquid
Purity (GC)≥98.0%
Density0.793 g/cm3
Boiling Point16°C
Melting Point-74°C
Flash Point-35°C
Refractive Index1.338

Industrial Applications

The utility of Fluoro(trimethyl)silane extends across multiple sectors within the chemical industry. In pharmaceutical manufacturing, it is employed to protect hydroxyl groups during multi-step synthesis routes, ensuring high yields and selectivity. Furthermore, its role as a fluoride source is critical in the preparation of specific API precursors where fluorine incorporation enhances metabolic stability and bioavailability.

Beyond pharmaceuticals, this silane derivative finds application in the modification of polymer surfaces and the synthesis of specialty silicones. Researchers utilize its unique reactivity to develop novel materials with enhanced thermal stability and chemical resistance. The versatility of this compound allows it to function effectively in both laboratory-scale discovery and large-scale production environments.

Quality Assurance and Safety

Quality control is paramount in our manufacturing workflow. Every batch undergoes rigorous gas chromatography (GC) analysis to verify purity levels exceeding 98.0%. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing physical constants and impurity profiles to ensure compliance with your internal specifications.

Regarding safety, this product is classified as a flammable liquid with a low flash point. It must be stored in a cool, well-ventilated area away from ignition sources and incompatible materials such as strong oxidizers. Proper personal protective equipment, including gloves and eye protection, is recommended during handling. We offer flexible packaging options, including standard 210-liter drums or customized containers based on specific logistical requirements.