Speciality Chemicals

Hexamethyldisilazane

  • CAS No.18297-63-7
  • GradeIndustrial / Pharmaceutical
  • Availability● In Stock

Premium grade Hexamethyldisilazane (HMDS) serving as a versatile silylation agent for pharmaceutical synthesis and semiconductor surface treatment.

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Product Technical Details

Product Overview

Hexamethyldisilazane, commonly abbreviated as HMDS, stands as a critical reagent in the realm of advanced organic synthesis and material science. As a premier supplier of fine chemicals, we provide high-purity HMDS designed to meet the rigorous demands of pharmaceutical manufacturing and semiconductor processing. This organosilicon compound is renowned for its effectiveness as a silylation agent, facilitating the protection of hydroxyl groups and enhancing the hydrophobicity of various substrates.

Our manufacturing process ensures consistent quality and reliability, making this product an ideal choice for large-scale industrial applications. Whether utilized in the synthesis of complex antibiotic derivatives or as a priming agent for photoresists, our HMDS delivers superior performance and reproducibility.

Key Specifications

ParameterSpecification
CAS Number18297-63-7
Purity99% Minimum
AppearanceColorless liquid
Density0.774±0.003 g/cm³
Refractive Index1.048±0.002
Packaging25kg Cardboard Drum

Industrial Applications

The versatility of Hexamethyldisilazane extends across multiple high-value industries. In the pharmaceutical sector, it plays a pivotal role during the synthesis of beta-lactam antibiotics, including penicillin and cephalosporin derivatives. It acts as an efficient protecting group agent, ensuring high yield and purity in complex molecular constructions.

Beyond pharmaceuticals, HMDS is indispensable in the semiconductor industry. It serves as a bonding aid for photoresists, improving adhesion on silicon wafers and enhancing the precision of lithography processes. Additionally, it is widely used for the surface treatment of inorganic powders such as diatomite, silica, and titanium dioxide, modifying their surface energy to improve dispersion in polymer matrices.

  • Effective silylation reagent for organic synthesis
  • Surface modification agent for fillers and pigments
  • Adhesion promoter in microelectronics fabrication
  • Intermediate for producing silicone-based materials

Quality Assurance and Handling

We adhere to strict quality control protocols to ensure every batch meets international standards. Each shipment is accompanied by a Certificate of Analysis (COA) verifying purity and physical constants. Proper handling is essential due to the chemical nature of the product. It should be stored in a cool, well-ventilated area away from incompatible materials such as strong oxidizing agents.

Our standard packaging consists of secure 25kg cardboard drums designed to maintain integrity during global transit. The shelf life of the unopened product is typically one year when stored under recommended conditions. We are committed to providing safe, compliant, and high-performance chemical solutions to our global partners.