N,O-Bis(trimethylsilyl)trifluoroacetamide

Product Overview

N,O-Bis(trimethylsilyl)trifluoroacetamide, widely recognized in the chemical industry by its acronym BSTFA, is a highly efficient silylating agent utilized extensively in organic synthesis and analytical chemistry. This colorless transparent liquid functions as a powerful protective group donor, facilitating the derivatization of compounds containing active hydrogen atoms such as hydroxyl, amino, and thiol groups. Our manufacturing process ensures exceptional purity levels, making it an ideal choice for demanding laboratory applications and large-scale industrial synthesis protocols.

As a leading supplier in the specialty chemicals sector, we provide BSTFA that meets rigorous international quality standards. The reagent is particularly valued for its ability to enhance the volatility and thermal stability of polar compounds, which is critical for gas chromatography (GC) and mass spectrometry (MS) analysis. By replacing active hydrogens with trimethylsilyl groups, BSTFA enables precise identification and quantification of complex molecular structures.

Key Applications

The versatility of N,O-Bis(trimethylsilyl)trifluoroacetamide extends across multiple domains of chemical research and production. In pharmaceutical manufacturing, it serves as a crucial intermediate in the synthesis of complex active pharmaceutical ingredients (APIs) and steroid derivatives. The reagent is employed to protect sensitive functional groups during multi-step synthesis routes, ensuring high yield and selectivity.

• Analytical Chemistry: Primary choice for GC-MS sample derivatization to improve detectability.
• Pharmaceutical Intermediates: Essential for synthesizing complex therapeutic compounds and steroid-based medications.
• Organic Synthesis: Used as a protecting group for alcohols, amines, and carboxylic acids.
• Quality Control: Supports accurate analysis of raw materials and finished products in regulated industries.

Technical Specifications

Safety and Storage

Proper handling and storage are essential to maintain the integrity and safety of N,O-Bis(trimethylsilyl)trifluoroacetamide. This product is classified as a Dangerous Good Class 3 flammable liquid. It should be stored in the original unopened container at temperatures of 25℃ or below to prevent degradation. The shelf life of this product is one year from the date of production when stored under recommended conditions. Expired products should not be discarded immediately but can only be used after passing rigorous quality control tests to ensure potency and safety.

Packaging and Quality Assurance

We offer flexible packaging options to suit various operational scales, including 25Kg, 50Kg, and 160Kg iron drums. Each batch is accompanied by a Certificate of Analysis (COA) verifying purity and physical properties. Our global manufacturing network ensures consistent supply chains and competitive bulk pricing for partners worldwide. Commitment to quality assurance and regulatory compliance makes us a trusted partner for your chemical sourcing needs.