Speciality Chemicals

Trifluoroacetic Acid

  • CAS No.76-05-1
  • GradeIndustrial / Pharmaceutical
  • Availability● In Stock

High purity Trifluoroacetic Acid (TFA) CAS 76-05-1, essential for peptide synthesis and organic fluorination. Reliable bulk supply from certified manufacturer.

Request a Quote & Full COA

Product Technical Details

Product Overview

Trifluoroacetic Acid (TFA) is a premier fluorinated organic compound widely recognized for its exceptional utility in modern chemical synthesis and pharmaceutical research. As a strong carboxylic acid, it serves as a critical reagent in various industrial processes, particularly where high acidity and solubility are required. Our manufacturing facility ensures that every batch meets rigorous international standards for purity and consistency, making it an ideal choice for demanding applications in organic chemistry and material science.

This compound is characterized by its unique chemical structure, where three fluorine atoms replace the hydrogen atoms of the methyl group in acetic acid. This substitution significantly enhances its acidity compared to non-fluorinated analogs. We provide this specialty chemical with a commitment to quality assurance, supporting clients in achieving optimal results in their synthesis workflows.

Technical Specifications

ParameterSpecification
CAS Number76-05-1
Molecular FormulaC2HF3O2
Molecular Weight114.02 g/mol
AppearanceTransparent Liquid
Density1.535 g/mL at 25 °C
Boiling Point72.4 °C
Melting Point-15 °C
Refractive Indexn20/D 1.3
Water SolubilityMiscible

Industrial Applications

The versatility of Trifluoroacetic Acid makes it indispensable across multiple high-tech sectors. Its primary role involves facilitating complex chemical transformations where standard acids may fail to provide the necessary reactivity or solubility profiles.

  • Peptide Synthesis: Widely used as a cleavage agent to remove protecting groups during solid-phase peptide synthesis.
  • Organic Fluorination: Serves as a key reagent for introducing fluorine atoms into organic molecules.
  • Chromatography: Employed as an ion-pairing agent in HPLC mobile phases for improved separation of biomolecules.
  • Material Science: Utilized in the development of new fluorinated polymers and advanced materials.
  • Pharmaceutical R&D: Essential solvent and catalyst in the development of new drug candidates.

Safety and Storage

Handling Trifluoroacetic Acid requires strict adherence to safety protocols due to its corrosive nature. It is incompatible with combustible materials, strong bases, and strong oxidizing agents. Personnel must utilize appropriate personal protective equipment, including chemical-resistant gloves and eye protection, during handling operations.

For optimal stability, store this product in a ventilated, low-temperature, and dry warehouse. It must be stored separately from oxidizers, alkalis, and cyanides to prevent hazardous reactions. Our packaging ensures secure transport while maintaining the integrity of the chemical throughout the supply chain. We provide comprehensive Certificates of Analysis (COA) with every shipment to verify compliance with safety and quality specifications.